八肽胆囊收缩素抗内毒素休克的实验研究  

CHOLECYSTOKININ-OCTAPEPTIDE (CCK-8)REVERSES EXPERIMENTAL ENDOTOXIN SHOCK

作　　者：凌亦凌[1] 黄善生[1] 王乐丰[1] 张君岚[1] 万梅 郝荣利 

机构地区：[1]河北医科大学基础医学研究所,河北医科大学病理生理教研室

出　　处：《生理学报》1996年第4期390-394,共5页Acta Physiologica Sinica

基　　金：国家自然科学基金

摘　　要：本实验观察了八肽胆囊收缩素（ＣＣＫ－８）对大鼠注入内毒素（８ｍｇ／ｋｇｂ．ｗ．ｉｖ）后血压、血液有形成分和脏器病理形态的影响，以及对醋酸铅致敏大鼠注入内毒素（１μｇ／１００ｇｂ．ｗ．ｉｖ）后２４ｈ死亡率的影响。结果表明，ＣＣＫ－８可使内毒素休克大鼠的血压明显回升（Ｐ＜０．０５），减轻血液浓缩和血小板、白细胞增多等血液有形成分的变化及主要脏器的损伤，降低２４ｈ死亡率。上述结果提示：ＣＣＫ－８确有逆转内毒素休克的作用，内毒素休克时内源性ＣＣＫ－８的释放，可能具有重要的保护作用。The effects of CCK-8 on the mean arterial pressure (MAP),blood components and path-morphological changes during endotoxin shock (endotoxin, 8mg/kg b,w. iv.)in rats,as well as on the 24 h mortality rate (MR) of the lead-sensitized rats in endotoxin shock (endotoxin 1μg/100g b.w.iv.)were observed.The results showed that injection of CCK in ES rats led to an increase in MAP,and a reduction of hematocrit and platelet as well as white cell count;the mortality rae decreased and the lesion in main organs lessened.it is suggested that release of endogenous CCK has important protective action during endotoxin shock.

关 键 词：胆囊收缩素 内毒素休克 药理学 

分 类 号：R977.6[医药卫生—药品] R631.405[医药卫生—药学]