兔颈迷走神经传入冲动抑制肾交感神经传出活动的延髓机制  

MEDULLARY MECHANISM OF THE INHIBITION ON RENAL SYMPATHETIC EFFERENT ACTIVITIES BY STIMULATION OF THE CERVICAL VAGAL AFFERENT NERVE IN RABBITS

作　　者：苏军达[1] 黄仲荪[1] 王莎莉[1] 陆杰[1] 

机构地区：[1]重庆医科大学生理教研室,上海医科大学生理教研室

出　　处：《生理学报》1996年第4期410-414,共5页Acta Physiologica Sinica

摘　　要：实验在６３只戊巴比妥纳麻醉、制动和人工呼吸条件下的家兔身上进行。刺激颈部一侧迷走神经中枢端（ＣＶＮ）引起肾交感神经传出放电（ＲＳＮＤ）抑制反应，抑制时间为：３．６±０．１８ｓ。这种抑制时间的长短与动物当时ＣＮＳ机能状态、交感神经活动的背景水平有关。通过记录延髓头端腹外侧区（ＲＶＬ）和尾端腹外侧区（ＣＶＬ）的细胞放电变化，表明ＣＶＮ传入冲动可能是通过孤束核（ＮＴＳ）引起ＣＶＬ兴奋及ＲＶＬ的抑制，从而使交感神经传出活动发生抑制。Experiments were performed on 63 rabbits anesthetized with pentobarbital, paralyzed with gallamine triethiodide and ventiled artifically. lpsilateral renal sympathetic nerve discharge (RSND), unit discharges of rostral ventrolateral medulla (RVL), caudal ventrolateral medulla (CVL) and blood pressure (BP) were recorded. The sympatho-inhibitory response were evoked by stimulation of the central end of vagal nerve (CVN ) (731 /788 exp. ). The inhibitory duration is 3. 6±0.180 s. The responses vary with the functional state of the CNS. The RSND inhibitory duration could be shortened or prolonged, depending on the excitatory background of RSND or the basal sympathetic tonic activity. The results. indicate that CVN-induced inhibitory of RSND may be mediated, at least partly, by excitation of NTS and CVL, which results, in turn, in depressing RVL and final reduction of sympathetic efferent activity.

关 键 词：迷走神经 传入冲动 传出活动 延髓 

分 类 号：R338.3[医药卫生—人体生理学]