损毁成体鸽下丘脑腹内侧核对神经元增生的影响  

THE EFFECT OF LESION OF NUCLEUS VENTROMEDIALIS HYPOTHALAMI ON NEUROGENESIS IN ADULT RING DOVES

作　　者：左明雪[1] 

机构地区：[1]北京师范大学生物学系

出　　处：《生理学报》1996年第3期249-255,共7页Acta Physiologica Sinica

基　　金：国家自然科学基金

摘　　要：本实验应用［￣３Ｈ］放射自显影和免疫组织化学方法首次报道了高等脊椎动物成体乌脑损伤引起神经元增生的观察结果。电损毁非鸣禽成体环鸽（ＳｔｒｅｐｔｏｐｅｌｉａＲｉｓｏｒｉａ）下丘脑腹内侧核（ＶＭＮ）后能引起端脑外侧室带区（ＬＶＺ）中［￣３Ｈ］标记细胞的大量增生和在端脑尾部ＬＶＺ中的特异性分布。新生神经元的数量在全部端脑水平增加了１．６２倍，许多新生神经元集中分布在端脑尾部的新纹状体水平。这些结果表明：脑损伤引起了ＬＶＺ中增殖细胞和新生神经元在端脑不同水平中的重新分布及增生数量的显著性变化，这种变化的原因可能与脑损伤本身和脑损伤的部位有关。结果提示：成鸽脑损伤诱发产生的新生神经元可能与某种程度的脑损伤修复、内分泌功能的改变等功能有关。In the present study the effects of lesion hypothalami ventromedialis nucleus(VMN) of ring dove (Streptopelia Risoria ) on neurogenesis regarding the lesion-induced change of distribution of proliferating cells in the lateral ventricular zone (LVZ) and new neurons in the non-ventricular zone (VZ) were studied by using [3H] thymidineautoradiographicand immunohistochemistry methods. The results showed that such lesion not only induced significant increase of neurogenesis in telencephalon (up to,1. 62 times of that of the intact doves), but also altered distribution patterns of the newborn neurons. Many of the new neurons confined in neostriatum medians and pars caudalis of telencephalon, where the crate of neurogenesis in intact dove is very low. Such kinds of neurogenesis in the birds with brain lesions may be region-dependent and somewhat underlie brain repair and alteration of endocrine function after brain injury.

关 键 词：环鸽 下丘脑腹内侧核 脑损伤 新生神经元 

分 类 号：Q959.729[生物学—动物学]