尾核P物质对胃运动的抑制效应系通过黑质、迷走背核经迷走神经所介导  

INHIBITORY EFFECT OF SUBSTANCE P OF CAUDATE NUCLEUS ON GASTRIC MOTILITY VIA SUBSTANTIA NIGRA AND DORSAL VAGAL NUCLEUS MEDIATED BY VAGUS NERVE

作　　者：荆浩[1] 张健[1] 林坤伟[1] 

机构地区：[1]大连医科大学生理教研室

出　　处：《生理学报》1996年第3期269-276,共8页Acta Physiologica Sinica

基　　金：国家自然科学基金;辽宁省教委资助

摘　　要：本工作观察损毁下丘脑外侧区、黑质、迷走背核及其传出神经对尾核微量注射Ｐ物质（ｓｕｂ－ｓｔａｎｃｅＰ；ＳＰ）引起的胃肌电快波和胃运动抑制效应的影响。实验结果：该抑制效应不依赖于下丘脑外侧区的完整，但可被损毁黑质、迷走背核或迷走神经所消除。用利血平耗竭交感神经递质则不影响该效应。这些结果表明：尾核ＳＰ的抑胃效应系通过黑质、迷走背核经迷走神经所传出。Effects of lesion of bilateral hypothalamus (LH), substantia nigra and dorsal vagal nucleus as well as their efferent pathway on the inhibition of gastric myoeleetric fast wave and gastric motility due to injection of substance P (SP) to caudate nucleus were studied in rats. The experimental results showed that this induced inhibition was independent of the presence of intact LH but abolished by lesioning substantia nigra, dorsal vagal nucleus or vagus nerve. Depletion of sympathetic transmitter by reserpine did not affeet the occurrence of the inhibition. Thus, it appears that the gastric inhibitory effect of caudate nucleus SP is mediated via substantia nigra and dorsal vagal nucleus to vagus nerve.

关 键 词：下丘脑 尾核 P物质 黑质 迷走背核 胃运动 

分 类 号：R338.27[医药卫生—人体生理学]