大剂量X射线照射对雄性大鼠某些组织LPO水平及CuZn－SOD和Se－GSH－Px活性的影响  

EFFECT OF HIGH DOSE IRRADIATION ON LPO LEVELS AND CuZn SOD AND Se GSH Px ACTIVITIES OF SOME TISSUES IN MALE RATS

作　　者：孙铁华[1] 龚守良[1] 张铭[1] 刘树铮[1] 

机构地区：[1]白求恩医科大学

出　　处：《辐射防护》1996年第6期449-453,共5页Radiation Protection

摘　　要：本研究观察大剂量Ｘ射线照射雄性大鼠７２ｈ后免疫和内分泌等组织脂质过氧化物（ＬＰＯ）水平及超氧化物歧化酶（ＣｕＺｎ－ＳＯＤ）和谷胱甘肽过氧化物酶（Ｓｅ－ＧＳＨ－Ｐｘ）活性的变化。结果发现，胸腺、脾脏、肾上腺和肝脏ＬＰＯ水平随照射剂量的增加而增高；脾脏和肝脏ＣｕＺｎ－ＳＯＤ活性在４Ｇｙ以上剂量照射后即升高，但在１０Ｇｙ照后增高明显；胸腺和脾脏Ｓｅ－ＧＳＨ－Ｐｘ活性在４Ｇｙ以上剂量照射后即明显高于对照组，睾丸Ｓｅ－ＧＳＨ－Ｐｘ活性也有增高趋势，其中１０Ｇｙ组增高明显；但是。The present study was designed to observe lipoid peroxide (LPO) levels and CuZn superoxide dismutase (CuZn SOD) and Se glutathione peroxidase (Se GSH Px) activities of immune and endocrine tissues in male rats after X irradiation at 4-10 Gy. LPO levels in thymus, spleen, adrenal and liver increased with increase of doses. Spleen and liver CuZn SOD activities increased after irradiation at 4 Gy or more, and significantly in 8 Gy or 10 Gy groups. Thymus and spleen Se GSH Px activities after 4 Gy or more irradiation were significantly higher than that in 0 Gy group. Testis Se GSH Px activity also tends to increase after irradiation, and significantly in 10 Gy group. But, thymus CuZn SOD and adrenal gland Se GSH Px activities decreased after 4 Gy or more irradiation. The above mentioned results are further discussed. (

关 键 词：辐射损伤 脂质过氧化物 X射线 大鼠 

分 类 号：R818.74[医药卫生—放射医学] Q691[医药卫生—临床医学]