慢性阻塞性肺疾病患者家庭长期氧疗的临床研究  

Clinical research on domiciliary long-term oxygen therapy for patients with chronic obstructive pulmonary disease

作　　者：刘华[1] 王华[1] 陈艳波[1] 王洪云[1] 

机构地区：[1]广东药学院附属第一医院,广州510080

出　　处：《现代生物医学进展》2006年第5期32-34,共3页Progress in Modern Biomedicine

基　　金：广东省医学科学技术研究基金资助项目【基金编号:A2005514】

摘　　要：目的:探讨家庭长期氧疗(LTOT)对慢性阻塞性肺疾病(COPD)患者的疗效。方法:将我院同期住院病人随机分为LTOT组(51人),对照组(52人)。全部病例在缓解期及治疗后每年测定PaO2、PaCO2、FVC、FEV1、HB、HCT的数值及每年住院次数。结果:①氧疗后12、、3、4、5年与氧疗前比较,低氧血症改善,FEV1明显提高,HB、HCT明显减少;每年住院次数减少;②LTOT组5年生存率62.75%,对照组5年生存率46.15%,差异有显著性(p<0.05)。结论:合理使用LTOT对COPD患者有良好的治疗作用,可提高患者的5年生存率。Objective： To observe the therapeutic effect of domiciliary long- term oxygen thempy（LTOT）on patients with chronic obstructive pulmonary disease（COPD）, with 5 - year- survival rate. Methods： The patients, who were admitted to hospital during the corresponding period, were randomly divided into LTOT group （n=51） and control group（n= 52）. Values of PaO2, PaCO2, FVC, FEV1, HB and HCT were examined at remission phase or annually after treatment, and admissions to emergency department were recorded. Results： （ 1 ） The admissions to emergency department, dyspnea, hypoxemia, index of lung function and arterial gas analysis were greatly improved after LTOT. （2） The 5 - year survival rote （62.75%） in LTOT group was significantly more than that in control group （46.15%, p〈 0.05）. Conclusion： The reasonable use of LTOT can achieve a good therapeutic effect on patients with COPD, which can improve their 5 - year- survival rote.

关 键 词：家庭长期氧疗 慢性阻塞性肺疾病 血气分析 肺功能 5年生存率 

分 类 号：R541.5[医药卫生—心血管疾病]