云南鼠疫菌对42种抗生素的敏感性试验  

The test of sensitivity of Yersinia pestis in Yunnan Province to 42 kinds of antibiotics

作　　者：梁云[1] 胡晓玲[1] 洪梅[1] 苏丽琼[1] 

机构地区：[1]云南省地方病防治所鼠疫防治研究中心,大理671000

出　　处：《中国地方病学杂志》2006年第5期497-499,共3页Chinese Jouranl of Endemiology

基　　金：云南省科技攻关计划资助项目(2002NG17)

摘　　要：目的通过鼠疫菌对新型抗菌药物的敏感性实验．寻找比链霉素敏感性更高且毒性小的药物。方法采用纸片扩散(K-B)法,按照美国临床试验标准委员会(NCCLS)(1993年版)法规进行检测。结果除大环内酯类抗菌活性差外,其他30种抗菌药物抗菌活性高于链霉素,处于各类抗生药物前2位的是：青霉素类的氨苄青霉素/舒巴坦、氨苄青霉素,头孢菌素类的头孢他啶、头孢唑啉,氨基糖甙类的庆大霉素、小诺霉素,氯霉素类的氯霉素,多粘菌素类的多粘菌素B,喹喏酮类的诺氟沙星、氧氟沙星,磺胺类的复方新诺明。结论为新型抗菌药物治疗实验动物鼠疫提供参考资料。Objective Through testing the sensitivity of Yersiniapestis to new types of antibiotic, to find more sensitive and less poisonous drug. Methods K-B method was used according to American＇s NCCLS statute. Results Except for macrolides, the other 30 kinds of antibiotics were all more sensitive than streptomycin. According to the results, the first two antibiotics of the kind were ampicillin/snlbactam, ampicillin of penicillins, and ceftazidime,cefazolin of cephalosprins. Then came aminoglycosides, quinolones and sulfamido. Conclusions The test provides some valuable reference data for the treatment of animal plague with new types of antibiotics.

关 键 词：鼠疫耶尔森菌 抗生素 微生物敏感试验 云南 

分 类 号：R446.5[医药卫生—诊断学]