中年健康男性中运动试验的变时性反应与颈动脉粥样硬化相关  

Chronotropic response to exercise testing is associated with carotid atherosclerosis in healthy middle-aged men

作　　者：Sae Y.J. Fernhall B. Heffernan K.S. 刘文秀 

机构地区：[1]Department of Kinesiology and CommunityHealth,College of Applied Life Studies,University of Illinois,Urbana-Champaign,1206 S.Fourth St,Champaign,IL 61820,United States

出　　处：《世界核心医学期刊文摘（心脏病学分册）》2006年第9期25-26,共2页

摘　　要：Aims: Chronotropic incompetence, an attenuated heart rate(HR) response to exer cise, is an independent predictor of cardiovascular mortality, but it is not kno wn whether chronotropic incompetence is related to carotid atherosclerosis. The association between chronotropic incompetence and carotid atherosclerosis in 856 7(age 47.6±8.8 years) healthy men was examined. Methods and results: Chronotrop ic incompetence was defined as the failure to achieve 85%of the age-predicted maximal HR(APMHR),< 80%HR reserve(HRR), and chronotropic response index(CRI). C arotid atherosclerosis was defined, using B-mode ultrasonography, as stenosis > 25%and/or intima-media thickness(IMT) of >1.2 mm. In multivariable adjusted lo gistic regression models, the subjects who achieved less than 85%of APMHR exhib ited an odds ratio(OR) of 1.72[95%confidence intervals(CI): 1.32-2.22] for car otid atherosclerosis. Subjects with< 80%of HRR were 1.45(95%CI: 1.14-1.84) ti mes more likely to have carotid atherosclerosis after multivariate adjustment. A lso, the OR of carotid atherosclerosis across quartiles of CRI(highest to lowest ) was 1.51(95%CI: 1.10-2.09) after multivariate adjustment. Conclusion: These results suggest that the chronotropic response to exercise is associated with ca rotid atherosclerosis, independent of the established risk factors in healthy me n, which could contribute to high incidence of cardiovascular diseases in subjec ts with chronotropic incompetence.Aims： Chronotropic incompetence, an attenuated heart rate （HR） response to exercise, is an independent predictor of cardiovascular mortality, but it is not known whether chronotropic incompetence is related to carotid atherosclerosis. The association between chronotropic incompetence and carotid atherosclerosis in 8567（age 47.6 ± 8.8 years） healthy men was examined. Methods and results： Chronotropic incompetence was defined as the failure to achieve 85% of the age-predicted maximal HR（APMHR）, 〈 80% HR reserve（HRR）, and chronotropic response index（CRI） . Carotid atherosclerosis was defined, using B-mode ultrasonography, as stenosis 〉 25% and/or intima-media thickness（IMT） of 〉 1.2 mm. In multivariable adjusted logistic regression models, the subjects who achieved less than 85% of APMHR exhibited an odds ratio （OR） of 1.72[95% confidence intervals（CI）： 1.32- 2. 22] for carotid atherosclerosis. Subjects with 〈 80% of HRR were 1.45（95% CI： 1.14 - 1.84） times more likely to have carotid atherosclerosis after multivariate adjustment. Also, the OR of carotid atherosclerosis across quartiles of CRI（highest to lowest） was 1.51（95% CI： 1.10 - 2. 09） after multivariate adjustment.

关 键 词：颈动脉粥样硬化 中年健康男性 变时性反应 运动试验 LOGISTIC回归模型 性功能不全 独立预测因素 内膜中层厚度 

分 类 号：R543.4[医药卫生—心血管疾病]