4-异丙基苯硼酸的合成与表征  

Synthesis and Characterization of 4-isopropylphenyl Boronic Acid

作　　者：张永强[1] 邓燕[1] 张华美[2] 贺全国[1] 

机构地区：[1]湖南工业大学绿色包装与生物纳米技术应用重点实验室,湖南株洲412008 [2]湖南大学机械与汽车工程学院,湖南长沙410082

出　　处：《化工时刊》2006年第9期40-41,共2页Chemical Industry Times

基　　金：湖南省普通高校青年骨干教师培训计划(2005-2008)资助

摘　　要：利用格氏试剂法合成了4-异丙基苯硼酸,得出了较佳的工艺路线:先制得格氏试剂(产率98.1%),然后与硼酸三丁酯在-10℃下亲核取代,快速升至室温,经酸性水解得产品,分离后总产率56.6%,对产品进行了核磁共振和质谱表征。4 - isopropylphenyl boronic acid was synthesized by Grignard reagent. Aoptimized process was obtained by investigating the influence of the temperature and reactant proportion on the yield. First, Grignard reagent was prepared （yield is 98.2% ）, and then reacted with tributyl borate at - 10℃, then hydrolyzed in an acid medium after the temperature was increased to room temperature in a short time. The isolated yield is 56.6%. The product was verified by ^1INMR and mass spectrum characterization.

关 键 词：格氏试剂 4-异丙基苯硼酸 合成 表征 

分 类 号：O627.8[理学—有机化学]