狼疮肾炎患者anti-GBM与anti-dsDNA和anti-NuA相关性研究  

Anti-GBM and Anti-ds DNA Associated with Anti-NuA in Patients with Lupus Nephritis

作　　者：李成海[1] 张聪恪[1] 赵静[2] 邹国林[3] 

机构地区：[1]河南省疾病预防控制中心,郑州市450083 [2]河南省人民医院中心实验室,郑州市450003 [3]武汉大学生命科学学院生物化学与分子生物学实验室,武汉市430072

出　　处：《医药论坛杂志》2006年第18期1-3,共3页Journal of Medical Forum

基　　金：国家自然科学基金项目资助(30370366)

摘　　要：目的探讨狼疮肾炎患者抗肾小球基底膜抗体(anti-GBM)与抗双链DNA抗体(anti-ds DNA)和抗核小体抗体(anti-NuA)的关系。方法反馈分析28例anti-GBM阳性的狼疮肾炎患者致肾炎抗体间的关系。结果28例anti-GBM阳性的狼疮性肾炎患者有13例anti-ds DNA阳性和17例anti-NuA阳性。并且,血清anti-GBM的水平与anti-ds DNA和/或anti-NuA水平一致。结论anti-GBM与anti-ds DNA和anti-NuA呈正相关;联合检测这些肾炎抗体对疾病的治疗和预后判断有指导意义。Objective To establish whether the anti - glomerular basement membrane anti- bodies （anti- GBM）correlate with anti -double stranded DNA antibody（ anti -dsDNA） and anti -nucleosome antibodies（anti - NuA） in patients with lupus nephritis （LN）. Methods 28 LN patients with anti -GBM were enrolled into the retrospective study. LN patient sera were previously tested for anti - GBM,anti - dsDNA and anti - NuA. Results At hospitalization, significant differences of serum anti -GBM levels were found in the LN patients with the presence and absence of anti -dsDNA（ 13 cases positive） and anti- NuA（ 17 cases positive）. Furthermore, serum anti- GBM levels were highly correlated with the presence of both anti - dsDNA and anti - NuA. Conclusion Anti - GBM, together with the additional nephritogenic potential of anti -dsDNA and anti -NuA, may play an essential role in the pathogenesis of the anti - GBM disease in LN.

关 键 词：狼疮性肾炎 抗肾小球基底膜抗体 抗双链DNA抗体 抗核小体抗体 

分 类 号：R593.242[医药卫生—内科学]