凉血和活血中药对银屑病患者进行期和静止期血浆中P物质、β-内啡肽分泌的影响  

Changes of SP and Beta-endorphin in Active and Quiescent Period of Psoriasis Patients Intervened by Blood-Cooling and Blood-Activating Herbs

作　　者：范斌[1] 李斌[1] 章云[1] 沈健雄[1] 赵小林[2] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院,上海200437 [2]第二军医大学生物学教研室,上海200433

出　　处：《上海中医药杂志》2006年第10期34-35,共2页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市高等学校科学技术基金项目(03ck08);上海市重点学科建设项目资助(T0304)

摘　　要：目的从凉血和活血中药对银屑病患者进行期和静止期血浆中神经肽的影响,探讨中医“血分论治”银屑病的作用机理。方法观察40例寻常型银屑病患者神经肽指标变化,以及凉血和活血中药对其干预作用。结果治疗前进行期(血热证)与静止期(血瘀证)之间,P物质(SP)存在差异(P<0.01)。治疗后P物质、β-内啡肽(beta-endorphin)分泌均有不同程度的下降(P<0.05或P<0.01)。结论中医“血分论治”是通过调节患者神经肽异常分泌,针对皮肤神经途径而发挥效能的。Objective To investigate the mechanism of using traditional Chinese hemo-modulating therapy to intervene the SP and beta-endorphin of psoriasis patients.Methods 40 ordinary psoriasis patients were treated by herbs and the expressions of SP and beta-endorphin were detected before and after treatment.Result Before treatment, the expression of SP showed differences in the active period and the quiescent period. After treatment,the expression of SP was decreased （P 〈 0.01） and E＆S Formula （P 〈 0.05）,as well as the expression of beta-endorphin was decreased （P 〈 0.01,P 〈 0.05）.Conclusion The traditional Chinese hemo-modulating treatment could effectively modulate the expression of SP and beta-endorphln of ordinary psoriasis in different periods.

关 键 词：寻常型银屑病 血分论治 P物质 Β-内啡肽 

分 类 号：R275[医药卫生—中医皮科]