肺部感染患者凝血和纤溶系统的监测  被引量：5

MONITORING ON THE CHANGES OF COAGULATION AND FIBRINOLYTIC SYSTEM IN LUNG INFECTION WITH MODS</em> <p class='article-op'> <span id="bdshare" class="bdshare_t bds_tools get-codes-bdshare baidufx"><span><span class="bds_more" style="display: block; width: 62px; height: 29px; background: url(/images/share.gif) no-repeat!important; padding: 0;"></span></span></span> </p> <p class="article-source"> <a href ='/article/read.aspx?id=22930310' class='btnTitle btnIsView' target='_blank'><img alt='在线阅读' src='/images/btn-read.png'/></a><a class='btnTitle btnIsView' href="javascript:showdown('2vVetOsYykPHi1kTafo2B6ZfNbXxCU7NGACT7zsHMNs=')"><img alt="下载全文" src="/images/btn-down.png" /></a> <input id="hiddowninfo" type="hidden" value="2vVetOsYykPHi1kTafo2B6ZfNbXxCU7NGACT7zsHMNs="/> </p> <div class="collect" style="display: none"> <h5>我的收藏</h5> <div class="cnt"> <p> 名 称：<input type="text" name="collTitle" id="collSumTitle" /> </p> <p> 注 释：<input type="text" name="collRemark" id="collSumRemark" /> </p> <p style="text-align: center;"> <a href="javascript:void(0)" onclick="g_collectSumOk();"> <img width="65" height="17" src="/images_new/collect_ok.png" alt="完成" /></a> <a href="javascript:void(0)" onclick="g_collectSumCancel();"> <img width="65" height="17" src="/images_new/collect_no.png" alt="取消" /></a> </p> </div> </div> </div> <form name="wxTransfer" method="post"> <input type="hidden" name="lid" value="" /> <input type="hidden" name="sip" value="" /> <input type="hidden" name="date" value="" /> <input type="hidden" name="co" value="" /> <input type="hidden" name="Title_C" value="" /> <input type="hidden" name="Writers" value="" /> <input type="hidden" name="Name_C" value="" /> <input type="hidden" name="Num" value="" /> <input type="hidden" name="Years" value="" /> <input type="hidden" name="Volumn" value="" /> <input type="hidden" name="GCH" value="" /> <input type="hidden" name="Vol" value="" /> <input type="hidden" name="BookID" value="" /> <input type="hidden" name="SubjectNum" value="" /> <input type="hidden" name="SpecialNum" value="" /> <input type="hidden" name="mirrorName" value="" /> <input type="hidden" name="UserID" value="" /> <input type="hidden" name="UserName" value="" /> <input type="hidden" name="sourceID" value="" /> </form> <script type="text/javascript" src="/scripts/transfer.min.js"></script> <div class="article-detail"> <p class='author'><strong>作　　者：</strong><a href='/writer/article.aspx?id=100000000344515' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e6%9c%b1%e6%83%a0%e8%8e%89%5d' title='朱惠莉[1]'>朱惠莉[1]</a> <a href='/writer/article.aspx?id=100000009090780' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e5%91%a8%e4%bc%8a%e5%8d%97%5d' title='周伊南[1]'>周伊南[1]</a> <a href='/writer/article.aspx?id=100000007668020' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e7%8e%8b%e5%81%a5%5d' title='王健[2]'>王健[2]</a> <em> </em></p><p class='organ'><strong>机构地区：</strong><a href='/organ/article.aspx?id=517&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e5%8d%8e%e4%b8%9c%e5%8c%bb%e9%99%a2%e5%91%bc%e5%90%b8%e5%86%85%e7%a7%91' title='[1]华东医院呼吸内科'>[1]华东医院呼吸内科</a> <a href='/organ/article.aspx?id=517&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e5%8d%8e%e4%b8%9c%e5%8c%bb%e9%99%a2%e8%a1%80%e6%b6%b2%e5%ae%9e%e9%aa%8c%e5%ae%a4' title='[2]华东医院血液实验室'>[2]华东医院血液实验室</a> <em> </em></p><p class='from'><strong>出　　处：</strong><a href='/journal/summary.aspx?gch=81670X' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=J%3d%5b%e8%80%81%e5%b9%b4%e5%8c%bb%e5%ad%a6%e4%b8%8e%e4%bf%9d%e5%81%a5%5d' title='老年医学与保健'>《老年医学与保健》</a>2006年第3期142-145,共4页<em>Geriatrics & Health Care</em></p><p class='fund'><strong>基　　金：</strong>上海市科学技术委员会科研计划项目(034119854)</p><p class='abstrack'><strong>摘　　要：</strong>目的明确肺部感染患者,尤其是并发MODS肺部感染患者凝血和纤溶系统的变化,以利及时处理,减少病死率。方法观察正常老年人、无MODS肺部感染患者和并发MODS肺部感染患者共83例,治疗前检测各种凝血因子、凝血酶原时间、活化的部分凝血活酶时间、纤维蛋白原、纤维结合蛋白和D-二聚体含量、抗凝血酶-Ⅲ、纤溶酶原、组织纤溶酶原活化物、纤溶酶原活化物抑制剂活性等凝血和纤溶指标;分析三组患者凝血和纤溶系统指标是否有差异,MODS患者生存者与死亡者,凝血、抗凝和纤溶系统指标是否有差异。结果肺部感染并发MODS患者,存在明显凝血、抗凝和纤溶系统异常;且该组死亡患者凝血、抗凝和纤溶系统异常情况比生存者更明显,故凝血、抗凝和纤溶机能异常者死亡率高。结论提示肺部感染者存在凝血、抗凝和纤溶机能的紊乱,可能与MODS的发生和预后有一定关系,可作为临床治疗和预测转归的观察指标。<em>Objective To investigate the significance of changes of coagulation and fibrinolytie system in patients of hmg infection with multiple organ dysfunction syndromes （MODS）. Methods Hematological examinations of 83 cases with various degrees of lung infection and the normal aged persons as control, such as estimation of PT, APTT, and D-Dimer, activator of FDP, FG, AT- Ⅲ , F Ⅱ , F Ⅴ , F Ⅶ . F Ⅹ . F Ⅷ . F Ⅸ, F Ⅺ , FⅫ were performed. The relationship between MODS and changes of coagulation and fibrinolytic system, the relationship among the prognosis and abnormities of coagulation and fibrinolytic system were observed. Results There was relation ship between MODS and abnormities of coagulation and fibrinolytic system. In patients of lung infection with MODS, the coagulation and fibrinolytic system were much more abnormal. The changes in patients suffering from MODS were more marked than those in patients without MODS. Conclusions It is suggested that patients of lung infection with MODS have dysfunction of coagulation and fibrinolytic system. The dysfunction of coagulation and fibrinolytic system associated with MODS may be used to direct the treatment and to tell the prognosis.</em></p><p class='subject'><strong>关 键 词：</strong><a href='/subject/article.aspx?id=6730810' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e8%82%ba%e7%82%8e%5d' title='肺炎'>肺炎</a> <a href='/subject/article.aspx?id=522820' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%a4%9a%e5%99%a8%e5%ae%98%e5%8a%9f%e8%83%bd%e8%a1%b0%e7%ab%ad%5d' title='多器官功能衰竭'>多器官功能衰竭</a> <a href='/zk/search.aspx?key=K%3d%5b%e7%93%b6%e6%b6%b2%e5%87%9d%e5%9b%ba%5d' title='瓶液凝固'>瓶液凝固</a> <a href='/zk/search.aspx?key=K%3d%5b%e7%ba%a4%e6%ba%b6%e8%9b%8b%e7%99%bd%e6%ba%b6%e8%a7%a3%5d' title='纤溶蛋白溶解'>纤溶蛋白溶解</a> </p><p class='class'><strong>分 类 号：</strong><a href='/zk/search.aspx?key=C%3dR563.1' title='R563.1'>R563.1</a>[<a href = '/domain/article.aspx?id=492' >医药卫生—呼吸系统</a>] </p> </div> <div id="content_wzxg" name="wzxg" class="article-graph"> <object width="695" height="250" classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" id="FlashID"> <param value="../flash/relation.swf" name="movie"> <param value="high" name="quality"> <param value="opaque" name="wmode"> <param value="6.0.65.0" name="swfversion"> <param value="dataUrl=/ajax/articlerelativegraph.ashx?id=22930310" name="flashVars"> <embed width="695" height="250" src="../flash/relation.swf" type="application/x-shockwave-flash" quality="high" wmode="opaque" flashvars="dataUrl=/ajax/articlerelativegraph.ashx?id=22930310"> </embed> </object> </div> <div class="article-relate-list"> <div class="relate-list"> <p id="ckwx_br"> </p> <h2 name="ckwx" id="ckwx">参考文献：</h2> <div id="listckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jckwx_br"> </p> <h2 name="2jckwx" id="2jckwx">二级参考文献：</h2> <div id="list2jckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="ohwx_br"> </p> <h2 name="ohwx" id="ohwx">耦合文献：</h2> <div id="listohwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="yzwx_br"> </p> <h2 name="yzwx" id="yzwx">引证文献：</h2> <div id="listyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jyzwx_br"> </p> <h2 name="2jyzwx" id="2jyzwx">二级引证文献：</h2> <div id="list2jyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="tbywx_br"> </p> <h2 name="tbywx" id="tbywx">同被引文献：</h2> <div id="listtbywx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="xgqklw_br"> </p> <h2 name="xgqklw" id="xgqklw">相关期刊文献：</h2> <div id="listxgqklw"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> </div> </div> <div class="article-about"> <div class="about-box"> <h5 class="name">相关的主题<tt><a class="hide" href="#"></a></tt></h5> <div class="about-list"> </div> </div> <div class="about-box"> <h5 class="name">相关的作者对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> <div class="about-box"> <h5 class="name">相关的机构对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> </div> </div> </div> <script type="text/javascript" src="/scripts/articlerelation.min.js"></script> <script type="text/javascript" src="/scripts/articlerightrelation.min.js"></script> <script type="text/javascript" src="/scripts/articledown.min.js"></script> <div class="layer-box download" id="downloadlayer" style="display: none"> <div class="close"> <a onclick="closedown()" href="javascript:void(0)"> <img src="/images/layer-close.png" width="21" height="21" alt="" /> </a> </div> <h5 class="layer-title">下载全文</h5> <div id="downloadinfo"></div> </div> <div class="layer-box download" id="downloadlayer2" style="display:none;min-height:100px;width:500px;"> <p> <img src="/images/loading2.gif" width="64" height="64"> <span style="font-size:20px;vertical-align:middle;padding-bottom:50px;">正在链接到云南高校图书馆文献保障联盟下载...</span> </p> </div> <script id="bdshare_js" data="type=tools&uid=0" type="text/javascript"></script> <script type="text/javascript"> $(function () { var rd = GetQueryString("rd"); 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