584例IVF-ET妊娠中输卵管妊娠危险因素分析  

Analysis of factors tube pregnancy in 584 pregnant with IVF-ET

作　　者：卢伟英[1] 徐雯[1] 吴玲[1] 黄元华[1] 

机构地区：[1]海南医学院附属医院

出　　处：《中国热带医学》2006年第10期1831-1833,共3页China Tropical Medicine

摘　　要：目的研究IVF-ET中发生输卵管妊娠的危险因素。方法回顾性分析自2000年1月～2006年5月在海南省生殖医学中心实施IVF-ET妊娠的584例孕妇的年龄、是否超排卵、机械因素和子宫内膜厚度对发生异位妊娠的影响,并采用多因素logistic多元回归分析其相关性。结果584例IVF-ET妊娠的孕妇中共计胚胎824个,输卵管妊娠率和胚胎异位种植率分别为7.2%和5.1%。按是否是超排卵周期移植、未超排卵周期移植、机械原因不孕和非机械原因不孕,输卵管妊娠率和胚胎异位种植率分别为8.4%和5.1%、2.6%和1.8%,9.1%和6.5%,5.1%和3.6%。前两者有显著性差异(P<0.05)。logistic多元回归显示超排卵因素与输卵管妊娠有关联(P=0.041,OR=3.462,95%CI1.051～11.453),机械因素与输卵管妊娠无显著关联(P=0.292)。以获卵数和注射hCG前子宫内膜厚度与输卵管妊娠行logistic多元回归显示获卵数量与输卵管妊娠无显著关联(P=0.257),子宫内膜厚度与输卵管妊娠有明显的关联(P=0.022,OR=0.879,95%CI0.787～0.982)。结论在IVF-ET中,超排卵可以明显增加输卵管妊娠的风险。增长较厚的子宫内膜有利于胚胎正常位置种植。Objective To anlayze the risk factors of tube pregnancy in IVF- ET. Methods 584 pregnancies admited in Affiliated Hospital of Hainan Medical College and received IVF- ET were retrospectively studies from Jan 2000 to May 2006. The x^2 test was used for counting data and muhivariable logistic regression was employed for multi - factor analyses. Results 824 embryos was gained in 584 pregnancies in whom tube pregnant rate and ectopic implantation rate are 7.2% and 5.1% respectively. The tube pregnant rate and ectopic implantation rate of factors of （controlled ovary hyperstimulation, COH）, non - COH, infertility associated with mehcanical factors and infertility without associated with mechanical factors were 8.4% and 5.1%, 2.6% and 1.8%, 9.1% and 6.5 % ,5.1% and 3.6 %, respectively showing significant differences （ P 〈 0.05 ）. Multiple - variate regression analysis was alsi made. The COH and infertility associated with mechanical factor was correlated with tubal pregnancy （ P = 0.041, OR = 3.462 with 95% CI 1.051 - 11.453）, the fertility assicated with mechanical facorts was not correlated with ubal pregnancy （P = 0.292）. The number of oocytes retrieved was not correlated with tubal pregnancy （ P = 0. 022, OR = 0. 879 with 95 % CI 0. 787 - 0.982）, and the number of ooeytes retrieved was correlated with tubal pregnancy （ P = 0. 257）. Conclusion In IVF - ET programs, the COH can increase the risk of tubal pregnancy and the increase of thickness of endometrium will decrease the risk.

关 键 词：体外受精-胚胎移植 输卵管妊娠 控制超排卵 子宫内膜 

分 类 号：R714.22[医药卫生—妇产科学]