高效液相色谱法测定盐酸班布特罗胶囊的含量  

HPLC Determination of the content of Banbuterol hydrochloride capsule

作　　者：韩刚[1] 翟丽[1] 王炳强[1] 张卫国[1] 

机构地区：[1]华北煤炭医学院药学系,唐山063000

出　　处：《药物分析杂志》2006年第9期1323-1324,共2页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:建立测定胶囊剂中盐酸班布特罗含量的方法。方法:采用高效液相色谱法对胶囊剂中盐酸班布特罗含量进行测定。色谱条件:色谱柱Agilent Zorba×SB-C_(18),150mm×4.6mm;流动相:磷酸缓冲溶液-甲醇-乙腈(45:16:25),流速1mL·min^(-1);柱温25℃;检测波长220nm。结果:线性范围25.2～201.6μg·mL^(-1)(r=0.9999),回收率99.74%,RSD= 0.82%。结论:高效液相色谱法测定胶囊剂中盐酸班布特罗的含量方法简便易行,准确度高,重现性好,可用于控制该制剂的质量。Objective：HPLC method to determined the content of Bambuterol hydrochloride has been established. Methods：The Agilent Zorbax SB -C18, 150 mm×4. 6 mm column was used with mobile phase phosphoric buffer solution -methanol- acetonitrile （45： 16：25 ） , the detection wavelenth was 220 nm. Result： The Linear concentration was within the range of 25.2 - 201.6μg·mL^- 1 （ r = 0. 9999 ）, and the average recovery was 99. 74% （ RSD = 0. 82%. Conclusion：The HPLC method to determined content of Banbuterol hydrochloride in capsule was simple and reliable. The method can be used to control the quality of preparation.

关 键 词：高效液相色谱法 盐酸班布特罗 胶囊剂 

分 类 号：R917[医药卫生—药物分析学]