参赤提取物对BSA致大鼠实验性肝纤维化的作用研究  

Effect of extract of paeonia lactiflora and salvia miltiorrhiza on liver fibrosis induced by BSA in Rats

作　　者：明志君[1] 曹莉[1] 王文祥[2] 陈可冀 

机构地区：[1]苏州大学药学院,江苏苏州215123 [2]苏州大学中国中医研究所,江苏苏州215123

出　　处：《南京医科大学学报（自然科学版）》2006年第10期925-928,F0003,共5页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:观察参赤提取物对牛血清白蛋白(BSA)致大鼠肝纤维化的治疗作用,为临床应用参赤提取物提供理论依据。方法:采用静脉注射BSA免疫性诱导大鼠肝纤维化模型。造模后,给予大鼠胃饲参赤提取物。检测大鼠血清肝功能及与肝纤维化相关的部分指标、肝组织羟脯氨酸含量(HYP),并对肝组织进行病理学观察。结果:参赤提取物可使BSA免疫性诱导的肝组织纤维增生、变性和坏死明显减轻。参赤提取物各组大鼠血清ALT、AST、HA、LN、PC-Ⅲ、IV-C及肝组织羟脯氨酸含量与模型组比较均显著降低;除低剂量组外,其余各给药组大鼠血清ALB较模型组显著升高。结论:参赤提取物具有保护肝细胞,维护肝功能,抗肝纤维化的作用,其作用机理与胶原代谢有直接的关系。Objective： To investigate the anti-liver fibrosis effect of extract of paeonia lactiflora and salvia miltiorrhiza in experimental rats. Methods： Rat liver fibrosis models were induced by injection of bovine serum albumin （BSA） in vein of tail. Rats were randomly divided into 6 groups, normal group, model group, positive control group treated by colchicines, and three PS groups （high, moderate and low dosage） The therapeutic effect on liver fibrosis of extract of paeonia lactiflora and salvia mihiorrhiza was investigated through gastrogavage. Results： Compared with model group, levels of serum albumin （ALB）, alanine transaminase （ALT）, aspartate aminotransferase （AST）, hyaluronic acid （HA） ,laminin （LN）, typeⅢ procollagen （PC Ⅲ ） and type Ⅳ collagen （ⅣC） in the treatment groups were obviously improved. It had significantly statistical difference （P 〈 0.05）. Pathological result showed that the liver fibrosis in PS groups was significantly improved. Conclusion：The extract of paeonia lactiflora and salvia miltiorrhiza has significant therapeutic effect on BSA-induced liver fibrosis in rats.

关 键 词：参赤提取物 肝纤维化 牛血清白蛋白 

分 类 号：R285.6[医药卫生—中药学]