水杨酸类糖酯化合物的合成及其生物活性  

Synthesis and Bioactivity of Salicylic Acid Saccharide Carboxylate

作　　者：臧洪俊[1] 李正名[2] 倪长春 沈宙 范志金[2] 刘秀峰[2] 

机构地区：[1]天津工业大学材料科学与化学工程学院 [2]南开大学元素有机化学研究所 [3]国家南方农药创制中心上海基地,上海200032

出　　处：《高等学校化学学报》2006年第10期1877-1880,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金重点项目(批准号:20432010);国家自然科学基金(批准号:30270883)资助.

摘　　要：将水杨酸及乙酰水杨酸分别与溴代糖作用,合成了10个水杨酸类糖酯化合物.所有化合物经元素分析和1HNMR确认了其结构,并证明产物为β-构型,反应具有立体专一性.生物活性初步测定结果表明,该类化合物具有一定的诱导活性,且一些化合物的诱导活性好于水杨酸.The plant activators such as salicylic acid and acetosalicylic act as a regulary molecue in plants which can stimulate the biosynthesis of phytoalexin to inhibit the growth of micobial patogens. In order to investigate the synergic effect of the glucose and salicylic acid, ten new glycosyl esters of salicylic acid were synthesized by the reaction of salicylic acid and acetosalicylic acid with acetylated glycosyl bromide. The structures were confirmed by elemental analysis and ^1 H NMR. The ^1 H NMR spectra showed that they were β-isomer. Bioassay results indicate that several compounds show a better induced activity against pathogen infection than salicylic acid.

关 键 词：水杨酸 乙酰水杨酸 糖酯 植物诱导抗性 生物活性 

分 类 号：O625[理学—有机化学]