药物累积法研究热痹清片的药物动力学  

Studies on the Toxicity and Effect Kinesics of Rebiqing Tablet

作　　者：刘雅敏[1] 张黎莉[2] 娄玉钤 李振国[2] 

机构地区：[1]河南中医学院,河南郑州450008 [2]河南省食品药品检验所,河南郑州450008 [3]河南风湿病医院,河南郑州450045

出　　处：《辽宁中医杂志》2006年第9期1171-1172,共2页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:研究热痹清片在小鼠体内的药物动力学过程。方法:采用药物累积法,以小鼠急性死亡率为指标,测定小鼠灌胃给药后不同时间的药物体存量,估算表观药物动力学参数。结果:药物毒性效应呈一级动力学过程,符合二房室模型。其动力学参数为:分布速率常数α和消除速率常数β分别为2.2272h-1及0.2031h-1;其分布半衰期t1/2α和消除半衰期t1/2β分别为0.3112h和3.4121h。结论:热痹清片小鼠灌胃给药易于吸收,毒性较大,分布快,但消除较慢。其表观药物动力学参数可为临床合理用药作参考。Objective： Research on pharmacodynamics of the Chinese medicine Rebiqing tablet in mouse intimate. Methods： Adopting drug accumulation , and using the mouse acute mortality rate as indicators to measure the different times after intragastrlc administration of the mouse and estimate apparent pharmacokinetics parameters. Results ： The effect of drug - toxicity shows the first order processes, and it consistents with the two compartment model. Its kinesics parameters as follow：α were 2. 2272 h^-1 and 13 were 0.2031 h^-1 ; t1/2α is 0. 3112h and relimination half life t1/2β is 3.4121h. Conclusion： The Rebiqing tablet is easy to absorb . It distributes fast and eliminates slow. Its causing death dosage and pharmacokinetic parameters can provide reference for clinical rational administration.

关 键 词：热痹清片 制马钱子 药物累积法 药物动力学 

分 类 号：R285.4[医药卫生—中药学]