润燥灵胶囊加腮腺内注射治疗干燥综合征的疗效观察  

Clinical Observation on Sjogren’s Syndrome Treated by Runzaoling Capsule Combined with Intraparotid Injection

作　　者：钟起诚[1] 张庆昌[1] 王振亮[1] 蒋富斌[1] 张欣[1] 朱秀惠[1] 张丽慧[1] 陈金莲[1] 袁国强[1] 郑国[1] 张水艳[1] 李慧云[1] 

机构地区：[1]河北医科大学附属以岭医院,河北石家庄050091

出　　处：《中国中医药信息杂志》2006年第10期24-27,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：河北省科技厅2001年立项课题(012761198)

摘　　要：目的探讨腮腺内直接注射用药对原发性干燥综合征(Sjogren’ssyndrome,SS)的疗效与作用机制,验证局部注射用药对已遭免疫反应破坏的腮腺腺体形态结构的修复和未损腺泡保护作用以及腮腺分泌唾液功能的改善作用。方法将已确诊为SS的患者分为对照组和治疗组,两组均用相同剂量的中成药润燥灵胶囊治疗,治疗组加直接腮腺内注射药物治疗,观察治疗前后两组腮腺结构、形态学表现和功能改善情况。结果两组在形态结构上的变化有显著差异(t=1.67,P<0.01),两组分泌唾液的功能比较差异有显著性意义(t=2.31,P<0.001)。结论腮腺内直接注射药物治疗能够修复免疫性炎症浸润但腺体尚未彻底破坏的腮腺腺泡和导管,能有效改善腮腺分泌唾液的功能。Objective To discuss the curative effect and functionary mechanism of intraparotid injection on Sjogren＇s syndrome （SS）, validate the action of restoring the parotid configuration destroyed by immunoreaction and protecting unspoiled parotid, testify the action of improving the function of parotid excreting saliva by intraparotid injection. Methods Patients diagnosed as SS were divided into control group and treatment group. The patient of two groups were all treated by the same dosage hormone and Runzaoling capsule, at the same time, the treatment group were added the intraparotid injection. The parotid configuration, morphologic manifestation and functional melioration were observed. Result There was remarkable difference about the change of parotid configuration （t=1.67, P〈0.01） and excretive function （t=2.31, P〈0.001） between two groups. Conclusion Intraparotid injection can restore the parotid gland and trachea which were immuno-inflammatory infiltration but unspoiled drastically, and improve the parotid function of excreting saliva effectively.

关 键 词：干燥综合征 润燥灵胶囊 腮腺内注射 

分 类 号：R442.8[医药卫生—诊断学]