瘢痕疙瘩组织中c-myc、ras原癌基因的表达  

Expression of C-Myc and Ras Proto-Oncogene in Keloid Tissue

作　　者：林开文 郑晓冬 刘保平[3] 

机构地区：[1]许昌市中心医院核医学科,河南许昌461000 [2]许昌县人民医院,河南许昌461000 [3]郑州大学医学院第一附属医院核医学科,河南郑州450052

出　　处：《医学信息（西安上半月）》2006年第10期1799-1801,共3页Medical Information

摘　　要：目的探讨c-myc、ras原癌基因表达与瘢痕疙瘩形成的关系。方法应用免疫组织化学方法检测c-myc、ras p21蛋白在30例瘢痕疙瘩组织和26例正常皮肤组织中的表达和分布。结果c-myc蛋白在瘢痕疙瘩成纤维细胞中呈强阳性表达,与正常皮肤对照组相比,差异有显著性(P<0.001),在瘢痕疙瘩的成纤维细胞中,ras p21蛋白缺乏表达。结论瘢痕疙瘩中c-myc蛋白表达升高提示c-myc原癌基因的激活,c-myc原癌基因可能参与了成纤维细胞的分化增殖、胶原合成与降解以及对细胞因子的调控,并导致瘢痕增生;ras原癌基因在瘢痕疙瘩形成中可能不突变或不起主要调控作用,这可能是瘢痕疙瘩较少癌变的原因。Objective： To investigate the relationship between the experssion of c - myc, ras proto - oncogene and the formation of keloids. Metheds： Immunohistochemical technique was used to determine the expression and distribution of c -myc, ras p21 proteins in 30 cases of keloids and 26 cases normal skin tissues. Results： The expression of c - myc protein in the fibroblasts in keloids was significantly higher than that in the fibroblasts in normal skin （P 〈 0.001 ）. Ras p21 expression was hot detected in the fibroblasts of kcloids. Conclusion： The elevated expression in the keloids indicates the activation of c - myc oncogene,which may contribute to the proliferation and differentiation of the fibroblasts and may participate in the synthesis and degradation of collagen,the regulation of cytokines and the formation of keloids ; ras proto - oncogene may not mutate or its mutations may not play a major role in the formation process of keloids, which may explain the canceration of these keloids.

关 键 词：C-MYC蛋白表达 瘢痕疙瘩组织 ras原癌基因 瘢痕疙瘩成纤维细胞 C-MYC原癌基因 RASP21蛋白 免疫组织化学方法 正常皮肤组织 

分 类 号：R619.6[医药卫生—外科学]