蛋白酪氨酸磷酸酯酶-1B抑制剂的研究进展  

Advances in the inhibitors of protein tyrosine phosphatase-1B

作　　者：李文明[1] 徐为人[2] 王润玲[1] 

机构地区：[1]天津医科大学药学院,天津300070 [2]天津药物研究院,天津300193

出　　处：《中国新药杂志》2006年第18期1523-1526,共4页Chinese Journal of New Drugs

基　　金：国家973计划支持项目(2004CB518902)

摘　　要：蛋白酪氨酸磷酸酯酶-1B(PTP-1B)是蛋白酪氨酸磷酸酯酶(PTP)家族中最具代表性的成鼠,因其参与多种生理过程尤其是与机体对胰岛素的敏感性紧密相关,目前已经成为糖尿病和肥胖症治疗的新靶点。现从PTP简介、PTP-1B的结构、生理功能以及6类抑制剂的结构性质等方面进行综述。As one of the most members in the family of protein tyrosine phosphatases（PTPs）,protein tyrosine phosphatase-1B （PTP-1B） plays best-known roles in regulating physiological processes, especially in down regulation of insulin signaling. PTP-1B inhibitors may thus serve as novel medicinal agents for the treatment of type 2 diabetes mellitus and obesity. This article gives an overview of reports that have appeared in the primary scientific literatures on the development of PTP-1B inhibitors,including PTP-1B＇s structural characteristics and physiological functions as well as the structural properties of six kinds of the PTP inhibitors.

关 键 词：蛋白酪氨酸磷酸酯酶-1B 糖尿病 肥胖症 抑制剂 计算机辅助药物设计 

分 类 号：R977.15[医药卫生—药品]