亚热带地区肠道病毒对TOPV免疫干扰的研究  

Immune Interference of Enteroviruses to Immune Response of TOPV in Subtropticai Areas

作　　者：吴承民[1] 郑焕英[1] 任永礼[2] 何显林 郭永文[1] 龚富强[2] 林伟生[1] 黄渭泉[1] 苏万年[4] 迮文远[4] 

机构地区：[1]广东省卫生防疫站,广州510300 [2]惠州市卫生防疫站 [3]惠东县卫生防疫站 [4]卫生部北京生物制品研究所

出　　处：《中华流行病学杂志》1996年第4期233-235,共3页Chinese Journal of Epidemiology

摘　　要：1992～1993年在广东省惠东县进行亚热带地区肠道病毒对TOPV免疫干扰的研究,观察在夏、冬季基免的188名儿童肠道病毒带、排毒情况和服苗后血清抗体反应,还检测母乳和生活污水。结果TOPV免疫一或三次后,冬季各型抗体GMT比夏季高2.0～7.1倍,健康儿童服苗前肠道病毒带毒率为54.8%,夏季高于冬季:服苗前带毒与否,各型抗体GMT差异有显著性,不带毒者高于带毒者1.5～1.7倍;服苗前抗体≤1:16者,服苗后各型抗体GMT冬季高于夏季。To study whether enteroviruses interfere with the immunoeffect of TOPV in subtroptical areas, a total number of 188 children were investigated 82 in summer, 106 in winter in two townships of Hui Dong County from 1992 to 1993. The carrier rates of enteroviruses and serum nutralization antibody titres of polio were tested before and after the children were vaccinated with TOPV. Data showed that the GMTs of poliovirus type Ⅰ, Ⅱ, Ⅲ in winter were 2 to 7.1 times as much as those in summer after administration of one and three doses TOPV. Enterovirus carrier rates were 75.6% and 38.8% respectively in summer and winter before vaccination in heal b children. The GMTs of polio serum antibody in children without enteroviruses was 1.5 to 1.7 times as much as the GMTs of those with enteroviruses, and the difference was statistically significant, Overall, the results demonstrated that enterovirus infection interfered the immune response of vaccinates to TOPV to some extent. It was also suggested that supplemental immunization was the key measure in polio eradication program and should he conducted in winter or spring seasons.

关 键 词：肠道病毒 TOPV 免疫干扰 亚热带地区 

分 类 号：R512.503[医药卫生—内科学] R373.2[医药卫生—临床医学]