碘硒缺乏对大鼠脑脂类含量的影响  

Effects of combined iodine and selenium deficiency on lipid content in brain of rat

作　　者：阎玉芹[1,2,3] 王丹娜[1,2,3] 刘守军[1,2,3] 张兆军[1,2,3] 钱明[1,2,3] 项建梅[1,2,3] 陈祖培[1,2,3] 邢雅珊 

机构地区：[1]天津医科大学内分泌研究所 [2]中国地方病防治研究中心 [3]哈尔滨市卫生检疫所

出　　处：《中国地方病学杂志》1996年第5期273-275,共3页Chinese Jouranl of Endemiology

摘　　要：按２×２析因实验设计将Ｗｉｓｔａｒ大鼠分成４组：Ｉ＋Ｓｅ＋、Ｉ＋Ｓｅ－、Ｉ－Ｓｅ＋和Ｉ－Ｓｅ－组。观察了碘硒两种因素及其联合作用对生后１５日、３０日龄仔鼠大脑总脂质，总磷脂及总胆固醇含量的影响。结果表明缺碘组（Ｉ－Ｓｅ＋和Ｉ－Ｓｅ－）三项指标的含量均明显低于补碘组（Ｉ＋Ｓｅ＋，Ｉ＋Ｓｅ－），而缺硒与补硒组之间无差别，提示缺碘组仔鼠存在脑髓化障碍。经析因方差分析表明，碘因素对上述指标的影响极为显著，而硒因素以及碘硒交互作用均未见明显影响。提示缺碘是影响脑脂类代谢即脑髓化障碍的主要原因。Wistar rats were randomly divided into 4 groups:I +Se +,I +Se -,I -Se + and I -Se - based on 2×2 factorial design.The effects of iodine,selenium and of their combined deficiency of brain lipid content were studied in 15 and 30 day rats after birth.The results showed that the contents of total lipid,phospholipid and cholesterol in iodine deficient groups(I -Se + and I -Se -) were much lower than those in iodine supplement groups(I +Se + and I +Se -),while there was no statistic difference between Se-deficient and Se-supplement groups,which indicated that retarded myelination in brain was caused by iodine deficiency.According to the factorial ANOVA,the significant effect of iodine factor on lipid content was found.Se factor and the combination of iodine and selenium showed no effect.The findings in this paper indicated that iodine deficiency was a major cause of retardation in brain myelination [WT5”HZ]

关 键 词：碘缺乏 碘缺乏 脑 磷脂 脂类代谢 

分 类 号：R591.1[医药卫生—内科学]