盐酸氮卓斯汀和丙酸氟替卡松治疗变应性鼻炎  

Clinical effect of azelastine hydrochloride and fluticasone propionate in treatment of allergic rhinitis

作　　者：冯慧伟[1] 范献良[1] 王喆[1] 张辉[1] 剪京芬[1] 

机构地区：[1]山东大学第二医院耳鼻咽喉科,山东济南250033

出　　处：《山东大学耳鼻喉眼学报》2006年第3期219-222,共4页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的：观察鼻用盐酸氮卓斯汀和丙酸氟替卡松单独应用及联合应用治疗变应性鼻炎的疗效。方法：采用随机对照的试验方法选择109例持续性变应性鼻炎患者（15～76岁，平均35．6岁），按照2004年兰州标准分为轻度和中、重度。轻度患者随机分为2组，分别予以盐酸氮卓斯汀和丙酸氟替卡松喷鼻，均为每鼻孔1掀，2次／d，疗程30d。中、重度患者随机分为3组，分别予以盐酸氮卓斯汀、丙酸氟替卡松（用法同上）和两药并用（两药间隔时间30min）。结果：轻度组盐酸氮卓斯汀和丙酸氟替卡松有效率分别为86．36％和92．00％，两组有效率差异无统计学意义（P〉0．05）。中、重度组单用盐酸氮卓斯汀（1组）、丙酸氟替卡松（2组）和两药并用（3组）的有效率分别为66．67％、73．33％和96．88％，1、2组有效率差异无统计学意义（P〉0．05），1、3组和2、3组差异均有统计学意义（P〈0．05）。盐酸氮卓斯汀组和丙酸氟替卡松组的总有效率分别为83．78％和90．00％，两组差异无统计学意义（P〉0．05）。结论：盐酸氮卓斯汀和丙酸氟替卡松可作为治疗变应性鼻炎的一线用药，二者联合可治疗中、重度变应性鼻炎。Objective： To observe the effect of azelastine hydrochloride and fluticasone propionate nasal spray in treatment of allergic dainitis. Methods： One hundred and nine patients （mean 35.6 yearslod, ranged from 15 to 76 yearslod） with persistent allergic rhinitis were randomized into mild, moderate or severe groups according to the ARIA. Patients of mild group received azelastine hydrochloride or fluticasone propionate one spray per nostril, two times per day for 30 days. Patients of moderate or severe group received azelastine hydrochloride or fluticasone propionate （with a 30-minute interval）, or their combination. Results： The effect in mild group was not significantly different between azelastine hydrochloride and fluticasone propionate（86.36% vs 92.00%, P 〉 0.05）. In moderate or severe groups, the response rate was 66.67%, 73.33% and 96.88% in azelastine hydrochloride （the first group）, fluticasone propionate alone（the second group） and their combination （the third group）. There was no significant difference between the first and the second groups （P 〉 0.05）. The response rate of the third group was significantly higher than that of the first and the second greups（both P 〈 0.05）. There was no significant difference between the total response rate of azelastine hydrochloride and of fluticasone propionate （83.78% vs 90.00%, P 〉 0.05）. Condusion： Azelastine hydrochloride and fluticasone propionate can be used for the first-line pharmacological treatment of allergic rhinitis, and their combination can be used to treat moderate or severe allergic rhinitis.

关 键 词：鼻炎 变应性 盐酸氮卓斯汀 丙酸氟替卡松 治疗结果 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]