盐酸左氧氟沙星滴耳液治疗中耳炎的疗效观察  

Efficacy of levofloxacin ear drop in the treatment of otitis media

作　　者：薛卫国[1] 孙洁[1] 金铮[1] 石文斌[2] 辛露[1] 林国经[3] 李加耘[4] 

机构地区：[1]青岛市立医院耳鼻咽喉-头颈外科,山东青岛266011 [2]青岛市立医院药剂科,山东青岛266011 [3]福建医科大学附属协和医院耳鼻咽喉-头颈外科,福建福州350000 [4]陕西省人民医院耳鼻咽喉-头颈外科,陕西西安710000

出　　处：《山东大学耳鼻喉眼学报》2006年第4期300-303,306,共5页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的:评价盐酸左氧氟沙星滴耳液治疗中耳炎的有效性和安全性。方法:采用同类有效药物氧氟沙星滴耳液作为对照,进行随机、双盲、阳性药物平行对照、多中心临床试验。结果:完成试验方案的可供疗效分析的患者120例,试验组和对照组各60例。试验组有效率为96.67%,细菌清除率为96.15%;对照组分别为85.00%和95.83%,两组差异无统计学意义(P均>0.05)。结论:盐酸左氧氟沙星滴耳液治疗中耳炎疗效显著,细菌清除率高,安全性好,与氧氟沙星滴耳液疗效相近。Objective： To observe the efficacy and safety of the levofloxacin ear drop in the treatment of otitis media. Method： A randomized, double-blind, multicenter, ofloxacin ear drop controlled trial was performed. Results： The data of 120 patients were analyzed, and 60 patients were in the group of levofloxaein ear drop and the other 60 in the group of ofloxaein ear drop. Efficacy assessment based on symptom score reducing index showed that the efficacy rate of levofloxacin ear drop was 96.67% and that of the ofloxacin ear drop was 85.00% ; the eradication rate of pathogens in the group of levofloxaein ear drop was 96.15% and in the group of ofloxaein ear drop was 95.83%. No significant difference was showed between two groups （ beth P 〈 0.05）. Conclusions： Levofloxacin ear drop is effective and safe in treating otitis media. The efficacy of levofloxacin ear drop is similar to that of ofloxaein ear drop.

关 键 词：中耳炎 左氧氟沙星 氧氟沙星 治疗结果 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]