心脑肾康对自由基清除作用的实验研究  

Experimental study the effects of XNSK on scavenging free radical

作　　者：简洁[1] 李春凤[2] 梁钢[3] 徐庆[1] 

机构地区：[1]桂林医学院药理教研室,广西桂林541004 [2]桂林医学院附属医院医务部 [3]广西医科大学药理教研室

出　　处：《中国老年学杂志》2006年第9期1237-1238,共2页Chinese Journal of Gerontology

基　　金：广西科技厅科研基金资助课题(No.桂科攻0235024-3)

摘　　要：目的研究心脑肾康对自由基的清除作用。方法连续给大鼠灌胃心脑肾康7 d后,以线栓法建立大脑中动脉梗死(MCAO)缺血再灌注模型,缺血1.5 h再灌注24 h后断头取脑,检测大脑皮层丙二醛(MDA)、超氧化物歧化酶(SOD)、一氧化氮(NO)、活性氧(ROS)、谷胱甘肽(GSH)含量。结果与模型组相比,高、中、低3个剂量心脑肾康用药后均能显著降低缺血后脑组织匀浆中MDA、NO、ROS含量,增加SOD、GSH活性(P<0.05)并呈剂量依赖性。其中,高剂量效果最好,优于阳性对照药(P<0.05)。结论心脑肾康具有良好的自由基清除作用。Objective To study the effects of Xinnaoshenkang （XNSK） on scavenging free radical. Methods The focal brain ischemia-reperfusion （middle cerebral artery occlusion, MCAO） model of rots given XNSK by intragastrical injection（ i. g. ） for 7 days were made by intraluminal monofilament method for 1.5 h and then reperfused for 24 h to detect the contents of MDA, NO, ROS, GSH and SOD in cerebral cortex homogenates from rots. Results XNSK at high, middle and low dosage decreased contents of MDA, NO, ROS and increased activity of SOD, GSH significantly （ P 〈 0. 05 ） comparing model group, having dosage dependency. The high dosage had the best effect than positive control group（ P 〈 0. 05 ）. Conclusions XNSK has good effects on scavenging free radical.

关 键 词：心脑肾康 自由基 清除作用 

分 类 号：R328.81[医药卫生—人体解剖和组织胚胎学]