转基因植物中使用抗生素抗性基因作为标记的安全性评价  

The hazard assessment for the use of antibiotic resistance genes as a marker in transgenic plants

作　　者：寇娅丽[1] 石磊[1] 

机构地区：[1]华南理工大学轻工与食品学院,广州510640

出　　处：《中国抗生素杂志》2006年第10期577-580,共4页Chinese Journal of Antibiotics

摘　　要：20世纪末,基因工程和生物技术取得突飞猛进的发展,转基因植物大量出现,带来了巨大的经济效益和社会效益,但同时也引发了许多安全性争议,部分原因在于它们构建过程中使用了抗生素抗性基因。本文以细菌DNA水平转移系统为根本出发点并结合目前使用较多的抗性基因的情况对其危害性进行评价,同时也对提高选择性基因安全性的策略作了简单论述。In the late 20th century, with the dramatic development of genetic engineering and biotechnology, a large number of transgenic plants emerged and brought enormous economic and social benefits. At the same time, they also raised the question of safety, partly due to the use of bacterial antibiotic resistance genes in their construction. In this paper, basing on the horizontal gene transfer system and the property of presently used antibiotic resistance genes; we evaluated their hazard consequences. Meanwhile, the methods for improving the bio-safety of selectable genes were briefly discussed.

关 键 词：转基因植物 抗生素抗性基因水平转移 危害性评价 

分 类 号：Q789[生物学—分子生物学]