美洛昔康贴片镇痛作用实验研究  

Study of analgesic on meloxican picking

作　　者：王彩霞[1] 王荣端[1] 张洪武[1] 刘玉兰[2] 

机构地区：[1]石家庄制药集团有限公司,河北石家庄050041 [2]沈阳药科大学药学院,沈阳110016

出　　处：《实用药物与临床》2006年第5期281-282,294,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的观察美洛昔康贴剂(Mel T)镇痛作用。方法观察Mel T对醋酸引起的小鼠扭体数的增加和甲醛所致的小鼠足痛值的降低,以及对佐剂性关节炎大鼠的痛阈值的影响。结果Mel T局部粘贴小鼠20、105、mg/kg,明显抑制由醋酸引起的小鼠扭体数的增加并降低甲醛所致的小鼠足痛值。大鼠足部粘贴14、7、3.5mg/kg,明显降低佐剂性关节炎大鼠的痛阈值,提高炎性足的压痛值。结论Mel T有明显的镇痛作用。Objective To investigate the analgesic effect of meloxican picking（Mel T）. Methods The analgesic actions of meloxican T were investigated by increase of body-twisting on mice and formaldehyde induced pain model, and the pain threshold value of rats paw by intradermal injection of complete Freund＇s adjuvant（CFA）. Results Mel T（20, 10, 5 mg/kg） could decrease the frequency of body torsion induced by acetic acid and inhibit the pain response induced by formadehyde. Mel T （14, 7, 3.5 mg/kg） could decrease the pain threshold value of CFA rats significantly. Conclusion The analgesic effect of Mel T is significant.

关 键 词：美洛昔康贴剂 镇痛作用 

分 类 号：R96[医药卫生—药理学]