动脉粥状硬化与血清中磷脂酰胆碱特异性磷脂酶C活性的相关性研究  

The Relationship between Atherosclerosis and Phosphatitylcholine Specific Phospholipase C Activity in Serum

作　　者：赵阳[1] 张立燕[2] 丁丽娜[1] 王楠[1] 金星[2] 苗俊英[1] 

机构地区：[1]山东大学生命科学学院发育生物学研究所,山东济南250100 [2]山东省立医院血管外科,山东济南250021

出　　处：《生物医学工程研究》2006年第2期89-92,共4页Journal Of Biomedical Engineering Research

基　　金：国家自然科学基金资助项目(30570749)

摘　　要：炎症在动脉粥状硬化(AS)形成过程中起关键作用,PC-PLC在炎症反应中扮演重要角色。为探讨PC-PLC活性与动脉粥样硬化的关系,本研究建立了动脉粥状硬化家兔模型,并用解毒活血颗粒灌胃,分别获得正常家兔血清、造模家兔血清和药物家兔血清,检测其中PC-PLC的活性。结果表明,造模组中钙离子依赖性和非钙离子依赖性两种PC-PLC活性均明显高于正常组,而加药组中这两种PC-PLC活性受到显著抑制。说明伴随动脉粥样硬化的发生,PC-PLC活性明显升高,而活血解毒颗粒能减轻动脉粥样硬化的程度,同时能显著抑制PC-PLC活性。Inflammation plays an important role in atherosclerosis （AS）. PC- PLC is a key factor in inflammation. To study the relationship between PC-PLC and AS, the models of AS in rabbit were developed and PC-PLC activity was assayed in normal, AS and therapeutic groups. We found that comparing with normal group, Ca^2＋- dependent and Ca^2＋ - independent PC- PLC activity in AS group increased, and comparing with AS group, the two kinds of PC- PLC activity in therapeutic group were inhibited. The result show that PC - PLC may be involved in atherosclerosis.

关 键 词：炎症 动脉粥状硬化 血清 磷脂酰胆碱特异性磷脂酶C 酶活 

分 类 号：R318[医药卫生—生物医学工程]