苯那普利对糖尿病肾病UALB、TGF-β_1、CⅣ和LAM影响  

Effect of benazepril on the excretion of urine microalbuminuria,TGF-β_1,type Ⅳ collagen and laminin in elderly patients with diabetic nephropathy

作　　者：杨俊[1] 计振民[1] 何畏[1] 周晨[1] 张鹏翎[1] 王昆[2] 刘超[2] 

机构地区：[1]江苏省省级机关医院老年科,江苏省南京市210024 [2]江苏省人民医院内分泌科,江苏省南京市210029

出　　处：《实用老年医学》2006年第5期314-316,共3页Practical Geriatrics

基　　金：中央保健委员会办公室专项资金科研课题(苏B047)

摘　　要：目的评价苯那普利对糖尿病肾病(DN)的临床疗效,并探讨相应作用机制。方法采用随机对照研究,观察苯那普利治疗前后DN患者24h平均尿微量白蛋白排泄量以及尿转化生长因子β1(TGF-β1)、层黏连蛋白(LAM)和Ⅳ型胶原(CⅣ)的变化。结果苯那普利治疗6月后,患者24h尿微量白蛋白平均排泄量为(0·044±0·034)g,尿TGF-β1为(1·48±0·59)μg/L,LAM为(22·74±23·26)μg/L量,CⅣ浓度为(13·47±10·94)μg/L量,均较治疗前有显著降低(P<0·05),而对照组则较基线值明显升高(P<0·05)。结论苯那普利可以有效降低血压、抑制肾脏TGF-β1、LAM及CⅣ的表达、显著减少DN患者尿蛋白的排出,从而发挥其肾脏保护作用。Objective To investigate the effect of benazepril on the patients with diabetic nephropathy （DN）. Methods Patients with DN were randomly assigned into control group and benazepril-treated group. Urinary microalbuminuria, TGF-β1, type Ⅳ collagen and laminin were detected at baseline and six months later. Results The level of urinary microalbuminuria,TGF-β1 ,type Ⅳ collagen and laminin was 0. 044 ±0. 034 g, 1.48 ±0. 59 μg/L, 13.47 ± 10. 94 μg/L, and 22. 74 ± 23.26 μg/L in benazepril treated group, respectively. Conclusions Benazepril can decrease blood pressure dramatically and prevent the development of DN through inhibiting the secretion of TGF-β1, type Ⅳ collagen and laminin.

关 键 词：血管紧张素转换酶抑制药 糖尿病肾病 转化生长因子 β 胶原Ⅳ型 老年人 

分 类 号：R587.1[医药卫生—内分泌] R972.4[医药卫生—内科学]