Enantioselective Addition of Phenylacetylene to Ketones Catalyzed by Chiral Amino Alcohols  

作　　者：丁娟 沈宗旋 罗晓清 陈维一 张雅文 

机构地区：[1]Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou, Jiangsu 215006, China [2]Suzhou Health School, Suzhou, Jiangsu 215007, China

出　　处：《Chinese Journal of Chemistry》2006年第10期1285-1289,共5页中国化学（英文版）

摘　　要：（S）-（1-Benzylpyrrolidin-2-yl）diphenylmethanol and cinchonine were evaluated as promotors in the asymmetric additions of phenylacetylene to ketones, in order to prepare chiral propargylic alcohols. Good yields （up to 89%） and moderate enantioselectivities （up to 77.9% ee） were achieved. Addition of Ti（OPr-i）4 can significantly improve the enantioselectivity of the reaction.（S）-（1-Benzylpyrrolidin-2-yl）diphenylmethanol and cinchonine were evaluated as promotors in the asymmetric additions of phenylacetylene to ketones, in order to prepare chiral propargylic alcohols. Good yields （up to 89%） and moderate enantioselectivities （up to 77.9% ee） were achieved. Addition of Ti（OPr-i）4 can significantly improve the enantioselectivity of the reaction.

关 键 词：chiral amino alcohol enantioselective addition PHENYLACETYLENE CINCHONINE 

分 类 号：O625.42[理学—有机化学]