A new Sequiterpenoid from Eupatorium adenophorum Spreng  

作　　者：何兰 杨婕 曹坳程 刘玉美 安玉 石建功 

机构地区：[1]Department of Chemistry, Beijing Normal University, Beijing 100875, China [2]Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100094, China [3]Institute ofMateria Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

出　　处：《Chinese Journal of Chemistry》2006年第10期1375-1377,共3页中国化学（英文版）

基　　金：Project supported by National Natural Science Foundation of China （No. 20372010）, Trans-Century Training Program Foundation for the Talents, Ministry of Education of China and Important technical research in agricultural structure regulation of agricultural department （No. 2003-11-04A）.

摘　　要：A new sequiterpenoid compound 8aa-hydroxy-l-isopropyl-4,7-dimethyl-l,2,3,4,6,8a-hexahydro-naphthalene-2,6- dione （1）, together with seven known compounds anti-HH-dimer-coumarin （2）, （-）-5-exo-hydroxy-borneol （3）, O-hydroxyl cinnamic acid （4）, 9β-hydroxy-ageraphorone （5）, 10Hα-9-oxo-ageraphorone （6）, 10Hβ-9-oxo- ageraphorone （7） and 9-oxo-10,11-dehydroageraphorone 8, was isolated from the leaves of Eupatorium adenopho- rum Spreng. The structures were elucidated by IR, ^1H and ^13C NMR, EIMS, HMBC and single-crystal X-ray spectral data.A new sequiterpenoid compound 8aa-hydroxy-l-isopropyl-4,7-dimethyl-l,2,3,4,6,8a-hexahydro-naphthalene-2,6- dione （1）, together with seven known compounds anti-HH-dimer-coumarin （2）, （-）-5-exo-hydroxy-borneol （3）, O-hydroxyl cinnamic acid （4）, 9β-hydroxy-ageraphorone （5）, 10Hα-9-oxo-ageraphorone （6）, 10Hβ-9-oxo- ageraphorone （7） and 9-oxo-10,11-dehydroageraphorone 8, was isolated from the leaves of Eupatorium adenopho- rum Spreng. The structures were elucidated by IR, ^1H and ^13C NMR, EIMS, HMBC and single-crystal X-ray spectral data.

关 键 词：Eupatorium adenophorum Spreng 8aα-hydroxy-l-isopropyl-4 7-dimethyl-l 2 3 4 6 8a-hexahydronaphthalene-2 6-dione 

分 类 号：R284.2[医药卫生—中药学]