An Efficient Method for Catalytic Asymmetric Reduction of Diketones and Application of Synthesis to Chiral 2,5- Diphenylpyrrolidine and 2,5-Diphenylthiolane  

作　　者：李响 赵刚 曹卫国 

机构地区：[1]Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China [2]Department of Chemistry, Shanghai University, Shanghai 200436, China

出　　处：《Chinese Journal of Chemistry》2006年第10期1402-1405,共4页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos. 20525208, 20532040, 20390050）.

摘　　要：Asymmetric reduction of diketones with borane reagents generated in situ using cheap and available NaBH4 and SnCl2 in the presence of （S）-（-）-α,a-diphenyl-2-pyrrolidinemethanol was successfully achieved to yield the corresponding chiral diols with excellent stereoselectivity and enantioselectivity. And the chiral diol was transformed into optically pure C2-symmetricl chiral amine or thioether.Asymmetric reduction of diketones with borane reagents generated in situ using cheap and available NaBH4 and SnCl2 in the presence of （S）-（-）-α,a-diphenyl-2-pyrrolidinemethanol was successfully achieved to yield the corresponding chiral diols with excellent stereoselectivity and enantioselectivity. And the chiral diol was transformed into optically pure C2-symmetricl chiral amine or thioether.

关 键 词：asymmetric reduction chiral diol chiral 2 5-diphenylpyrrolidine chiral 2 5-diphenylthiolane 

分 类 号：O625[理学—有机化学]