Synthesis of Fluoroalkylated Heterocycles via the Reaction of 3-（1-Hydropolyfluoroalkenyl）-l-oxo-2,4,1-benzoxazines with Dinucleophilic Reagents  

作　　者：杨先金 刘金涛 

机构地区：[1]College of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China [2]Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2006年第10期1418-1420,共3页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （No. 20172065）.

摘　　要：The reaction of 3-（1-hydropolyfluoroalkenyl）-1-oxo-2,4,1-benzoxazines 1 with some dinucleophiles was investigated. 7-Fluoroalkyl-2,3-dihydro- 1,4-diazepine[ 1,2-d]quinazolin- 11-ones 2, 2-fluoroalkylisoxazolo[3,2-b]quinazolin-9-ones 3 and 2-fluoroalkylbenzoimidazoles 4 were obtained from the reaction of 1 with 1,2-diaminoethane, hydroxylamine hydrochloride and 1,2-diaminobenzene respectively.The reaction of 3-（1-hydropolyfluoroalkenyl）-1-oxo-2,4,1-benzoxazines 1 with some dinucleophiles was investigated. 7-Fluoroalkyl-2,3-dihydro- 1,4-diazepine[ 1,2-d]quinazolin- 11-ones 2, 2-fluoroalkylisoxazolo[3,2-b]quinazolin-9-ones 3 and 2-fluoroalkylbenzoimidazoles 4 were obtained from the reaction of 1 with 1,2-diaminoethane, hydroxylamine hydrochloride and 1,2-diaminobenzene respectively.

关 键 词：fluoroalkylated heterocycle dinucleophile synthesis 

分 类 号：O623.2[理学—有机化学] O626[理学—化学]