A New Route to Z-5-Fluoro-2-methyl-1- （p-methylsulfinylbenzylidene）-3-indenylacetic Acid and Its X-ray Diffraction Analysis  

作　　者：曾卓 陈超森 金桂芳 赵经纬 朱士正 

机构地区：[1]College of Chemistry and Environment, South China Normal University, Guangzhou, Guangdong 510931, China [2]Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2006年第10期1443-1446,共4页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation 0f China （No. 20472106）.

摘　　要：The title compound （Sulindac） was prepared from the corresponding sulfinyl compound p-methylsulfinylbenzyl bromide by four-step reaction. The sole product （Z）-5-fuoror-2-methyl-l-（p-methylsulfinylbenzylidene）-3-indenyl acetic acid （Sulindac） was obtained and the E isomer of it was not found. X-ray single crystal diffraction analysis showed that the strong intermolecular hydrogen bonding and weak intermolecular hydrogen bonding coexisted in Sulindac.The title compound （Sulindac） was prepared from the corresponding sulfinyl compound p-methylsulfinylbenzyl bromide by four-step reaction. The sole product （Z）-5-fuoror-2-methyl-l-（p-methylsulfinylbenzylidene）-3-indenyl acetic acid （Sulindac） was obtained and the E isomer of it was not found. X-ray single crystal diffraction analysis showed that the strong intermolecular hydrogen bonding and weak intermolecular hydrogen bonding coexisted in Sulindac.

关 键 词：p-methylsulfinylbenzyl bromide Z configuration X-ray crystal structure intermolecular hydrogen bonding 

分 类 号：O625.7[理学—有机化学] O641.3[理学—化学]