2-氧代-2-[(2-氯-5-吡啶甲氨基)(芳基)甲基]-4-芳基-5,5-二甲基-1,3,2-二氧膦杂环己烷的合成及其生物活性研究  

Studies on the Synthesis and Biological Activities of 2-[(2-Chloro-5-pyridylmethylamino)(aryl)methyl]-4-aryl-5,5-dimethyl-1,3,2-dioxaphosphinane 2-Oxides

作　　者：孙凤梅[1] 石德清[1] 

机构地区：[1]华中师范大学化学学院农药与化学生物学教育部重点实验室,武汉430079

出　　处：《有机化学》2006年第10期1398-1402,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20302002)资助项目.

摘　　要：通过类Mannich反应“一锅法”合成了10个未见文献报道的含吡啶基的环状α-氨基膦酸酯,其结构经1HNMR,31PNMR,IR,MS和元素分析确证.测定了该系列化合物的杀虫、杀菌和除草活性,结果表明,所测化合物的杀虫活性不太好,但所有化合物在药液浓度为1.0×10-4g/mL时都具有较好的除草活性,部分化合物在5.0×10-5g/mL时显示出良好的杀菌活性.Ten novel cyclic α-aminophosphonates containing pyridine moiety were synthesized by ＂one pot＂ Mannich-type reaction. Their structures were confirmed by ^1H NMR, ^31p NMR, IR, MS spectra and elemental analysis. The prehminary biological activity tests show that all of the compounds have weak insecticidal activity but they have very good herbicidal activity at the concentration of 1.0 ×10^-4 g/mE, and some of the target compounds possess good fungicidal activity at the concentration of 5.0 ×10^-5 g/mE.

关 键 词：Α-氨基膦酸酯 2-氯-5-吡啶甲胺 合成 生物活性 

分 类 号：TQ453.2[化学工程—农药化工]