正交试验优选胃宁舒胶囊的提取工艺  

Optimization of Extracting Process for Weiningsu Capsules by Orthogonal Test

作　　者：俞忻璐[1] 管燕[1] 俞建平[2] 

机构地区：[1]浙江大学医学院附属邵逸夫医院,杭州310016 [2]浙江省药品检验所,杭州310004

出　　处：《中药新药与临床药理》2006年第5期366-367,共2页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的优选胃宁舒胶囊的提取工艺。方法以浸膏得率和柚皮苷含量为考察指标,采用正交试验法,考察加水量、提取次数、提取时间、药材浸泡时间4个因素对提取工艺的影响。结果最佳提取工艺为A3B2C2D3,即药材加水10倍量,提取2次,提取时间1.5h,浸泡时间1.5h。结论正交试验法优选胃宁舒胶囊的提取工艺简便、快速、准确。Objective To optimize the extracting process for Weiningsu Capsule. Methods With dry extract rate and naringin content as the inspection indicators, orthogonal test was used to investigate the influence of four extracting factors （water volume, extracting time, times of extracting and soak time of herbal） on the extracting process. Results The optimum extracting process was A3B2C2D3, i.e. the water volume being 10 times of the weight of medicinal material, extraction for two times and 1.5 hours each time, and soaking for 1.5 hours. Conclusion Optimization of extracting process for Weiningsu Capsule by orthogonal test is a simple, quick and accurate method.

关 键 词：正交试验 胃宁舒胶囊 浸膏得率 柚皮苷 

分 类 号：R284.2[医药卫生—中药学]