假病毒在丙型肝炎病毒研究中的应用  

Application of pseudotyped virus in research on hepatitis C virus

作　　者：黄睿[1] 凌世淦[1] 

机构地区：[1]军事医学科学院基础医学研究所,北京100850

出　　处：《军事医学科学院院刊》2006年第4期379-381,共3页Bulletin of the Academy of Military Medical Sciences

基　　金：国家"十五"重点科技攻关计划项目(2001BA705B06)

摘　　要：进行丙型肝炎病毒(HCV)研究的困难之一是缺乏方便实用的细胞培养体系,难以分离到大量的HCV。HCV假病毒是目前研究HCV感染早期阶段即病毒吸附、受体结合及与细胞膜融合等较理想的HCV替代模型。本文综述了HCV假病毒的构建方法及重要应用价值。Little is known about the early steps of hepatitis C virus （HCV） infection. This is mainly because of the difficulties in obtaining a sufficient quantity of native HCV virions from serum arising from the lack of an efficient cell culture system permissive for HCV infection. HCV pseudotyped virus is a model that can closely mimic the early steps of HCV infection. With this model,it should become possible to investigate HCV infection in detail and to identify novel HCV receptors. In this article, the production and the application of HCV pseudotyped virus are reviewed.

关 键 词：丙型肝炎病毒 假病毒 

分 类 号：R373[医药卫生—病原生物学]