MHA-bBMP仿生骨研制和实验研究  

Developmental and Experimental Study of Bionic Bone MHA-bBMP

作　　者：张开放[1] 闫宏伟[1] 刘凯[1] 刘涛[1] 

机构地区：[1]西安交通大学医学院第二附属医院骨科,陕西西安市710004

出　　处：《中国康复理论与实践》2006年第8期689-691,i0002,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：陕西省科技攻关项目(No.2002K10G8)

摘　　要：目的探讨MHAbBMP仿生骨做为替代骨对有限接触式钛网管固定下兔股骨干缺损模型的修复作用。方法48只新西兰大白兔分为实验组(MHAbBMP仿生骨+钛网管)和对照组(自体髂骨移植+钛网管)各24只。于股骨干中段截除10mm,建立兔股骨干缺损模型,将MHAbBMP仿生骨/自体髂骨植入骨缺损处加有限接触式钛网管固定修复骨缺损。术后观察动物的一般情况,检测血清碱性磷酸酶,进行X线片、病理组织、电镜等观察。结果钛网管固定稳定,两组动物的骨缺损均得到修复,血清碱性磷酸酶、X线片、病理组织和电镜检查数据无显著性差异。结论MHAbBMP仿生骨是一种高效生物活性替代骨,用其修复兔股骨干缺损的效果与自体髂骨相近。Objective To investigate the effort of MHA-bBMP implantation combined with limited contacted titanium net duct fixation on femoral shaft bone defect of rabbit. Methods 48 rabbits were divided into the experimental group （treated with bionic bone MHA-bBMP plus titanium net duck） and control group （treated with iliac autograft plus titanium net duct） with 24 animals in each group. The rabbit femoral shaft bone defect model was established by cutting 10 mm bone fragment off. After operation, bionic bone MHA-bBMP/iliac autograft was implanted into bone defect area and fixed with limited contacted titanium net duck. The general condition, serum alkaline phosphatase, X-ray, histopathologic examination and electron microscope were performed. Results The fixation stability of titanium net duck in two groups was good. The bone defect of two groups was repaired. The results of phosphatase, X-ray, histopathologic examination and electron microscope of two groups were not significantly different. Conclusion Bionic bone MHA-bBMP is a high bioactivity substitute, and can obtain therapeutic effect equal to iliac autograft when repairing rabbit＇s femoral shaft defect.

关 键 词：MHA—bBMP仿生骨 骨缺损 修复 兔 

分 类 号：Q811.2[生物学—生物工程]