血清高敏C反应蛋白与2型糖尿病大血管病变的相关性  

Association between hypersensitivity C-reactive protein and type 2 diabetic macrovascular complication

作　　者：邓红艳[1] 张雨[1] 符杰[1] 廖丽娅[1] 杨慕贤[1] 

机构地区：[1]武汉市普爱医院内分泌科,武汉430033

出　　处：《临床心血管病杂志》2006年第10期610-611,共2页Journal of Clinical Cardiology

摘　　要：目的:观察高敏C反应蛋白(hs-CRP)在2型糖尿病(DM)及DM伴大血管病变时的浓度变化。方法:84例2型DM患者按有无大血管病变分为伴大血管病变组(A组)44例,不伴大血管病变组(B组)40例,另选30例健康者作为正常对照组(C组),均检测血清hs-CRP值及糖化血红蛋白、空腹血糖、总胆固醇、三酰甘油,高、低密度脂蛋白胆固醇。结果:A组血清hs-CRP水平明显高于B组及C组(均P<0·01),B组高于C组(P<0·01)。结论:hs-CRP对DM患者发生大血管病变的预测具有重要意义。Objective： To investigate the hypersensitivity C-reactive protein （hs-CRP） Concentration in the pathogenesis of type 2 diabetes mellitus （DM）and its macrovascular complications. Method：The 84 cases of type 2 diabetes mellitus patients were divided into two groups （44 cases with macrovascular and 40 cases without as DM group） and 30 heathy subjects seved as a control group. Hyersensitivity C- reactive protein, glycosylated hemoglo- bin（ HbA1C）, fasting plasone glueose （FBG） ,TC,TG, HDL-C were measured. Result：The level of hs-CRP in type 2 diabetic patients with macrovascular complications （A） was significantly higher than those without macrovascular complications （B）and in the control group （C） ; the level of hs-CRP in group B was higher than that in group C. Conclusion：CRP seems to be a risk factor of type 2 diabetes and its macrovascular Complication, and plays an important role in risk prediction of the type 2 DM patients with macrovascular complication.

关 键 词：糖尿病 2型 C反应蛋白 大血管病变 

分 类 号：R587.1[医药卫生—内分泌]