硫氮酮对肥厚型心肌病患者左心室舒张早期血流传播速度的影响  

Diltiazem Effects on Left Ventricular Early Diastolic Flow Propagation Velocity in Patients with Hypertrophic Cardiomyopathy

作　　者：王志斌[1] 刘丽华[1] 李荣[1] 聂晶[1] 李艳[1] 孙品[1] 

机构地区：[1]青岛大学医学院附属医院心脏超声科,山东省青岛市266003

出　　处：《中国超声医学杂志》2006年第10期745-747,共3页Chinese Journal of Ultrasound in Medicine

摘　　要：目的检测硫氮酮对肥厚型心肌病(HCM)左心室舒张早期血流传播速度(VP)的影响。方法健康志愿者23例,非梗阻型HCM患者21例。HCM患者口服硫氮酮90mg,每日1次,共4周。彩色M-型多普勒测定用药前后VP变化。结果与正常组相比,HCM组VP明显减小(P<0.01);服药4周后,VP明显增加(P<0.01)。结论硫氮酮使HCM患者VP增加,表明VP对评价药物对左心室舒张功能治疗效应具有重要应用价值。Objective To investigate the effects of diltiazem on left ventricular early diastolic flow propagation velocity （Vp） in patients with hypertrophic cardiomyopathy （HCM）. Methods Twenty-three healthy volunteers and 21 patients with non-obstructive HCM were enrolled. Patients with HCM were treated with diltiazem administered 90 mg per day for 4 weeks, Vpwas measured using color M-mode Doppler before and after administration of diltiazem. Results Compared with the control group, Vpwas lower in HCM group （P〈0. 01）, After 4 week administration of diltiazem in HCM group, Vpwas increased significantly （P〈0. 01）. Conclusions Diltiazem causes Vpto be increased in patients with HCM, which demonstrated that Vp is important in assessing the drug effects on left ventricular diastolic function.

关 键 词：肥厚型心肌病 左心室舒张早期血流传播速度 硫氮[艹卓]酮 

分 类 号：R542.2[医药卫生—心血管疾病]