长期氧化应激导致葡萄糖对小鼠胚胎发育损伤的机制  

Mechanisms of Glucose Causing Mouse Embryo Damage by Chronic Oxidative Stress

作　　者：张雷[1] 方南洙[1] 李井春[1] 

机构地区：[1]延边大学农学院,动物遗传育种与繁殖实验室,龙井133400

出　　处：《细胞生物学杂志》2006年第5期661-666,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金资助项目(No.30270954)~~

摘　　要：葡萄糖是胚胎发育过程中所必需的重要能源物质之一,但当它长期过剩时,能够对胚胎发育造成损伤,而这一损伤正是通过多种代谢途径产生的活性氧(reactiveoxygenspecies,ROS)所致。对此,就葡萄糖引起胚胎氧化应激的一些机制进行简要回顾,并且为采用抗氧化手段是否可以阻止高糖对胚胎造成损伤这一构想提供一个参考。As one of important energy materials required for embryonic development, glucose in chorus excess causes embryo damage by reactive oxygen species （ROS）, which are from multiple metabolizable pathways of glucose. Here, this review provide an overview of these mechanisms that glucose cause oxidation stress to mouse embryos, as well as a consideration of whether antioxidant strategies might be used to protect against further damage of embryonic development after high glucose.

关 键 词：葡萄糖 活性氧 胚胎损伤 

分 类 号：Q954.4[生物学—动物学]