新型生化灭鼠剂对大白鼠半数致死剂量的研究  

Study on the LD_(50) of new bio-chemical rodenticide for lab mouse

作　　者：刘大鹏[1] 吴健[1] 顾健[2] 谢龄庆 

机构地区：[1]江苏省疾病预防控制中心,江苏南京210009 [2]江苏省卫生监督所,江苏南京210000 [3]江苏省爱卫会,江苏南京210009

出　　处：《中华卫生杀虫药械》2006年第5期365-367,共3页Chinese Journal of Hygienic Insecticides and Equipments

摘　　要：目的观察新型生化杀鼠剂对大白鼠的半数致死剂量，为指导用药提供科学依据。方法采用不同剂量、不同时间（d）灌胃的方法测试灭鼠剂的LD50。结果对试验鼠总体LD50为0．2041，95％可信限为0．1506～0．2765。对雄性试验鼠的LD50为0．1815，95％可信限为0．1178—0．2796。对雌性试验鼠的LD50为0、2302，95％可信限为0．1470～0．3604。结论该杀鼠剂可以有效杀灭试验鼠。Objective To observe the median lethal dose （LD50） of new bio-chemical rodenticide for lab mouse. Methods Testing the LD50 of bio-chemical rodenticide for lab mouse stomach pouring in series of dosages and days. Results The total LD50 for lab mice was 0. 204 1, 95% confidence interval was 0. 150 6 - 0. 276 5. The LD50 for lab male mice was 0. 181 5 , 95% confidence interval was 0. 117 8 - 0. 279 6. The LD50 for lab female mice was 0. 230 2, 95% confidence interval was 0. 147 0 - 0. 360 4. Conclusion The bio-chemical rodenticide could kill the lab mouse efficiently.

关 键 词：杀鼠剂 灭鼠 LD50 

分 类 号：R184.35[医药卫生—流行病学]