乙肝患者血清中sICAM-1与IL-18检测及临床意义  

Study on Relationship between sICAM-1,IL-18 Level Changes in Sera of the Patients with Chronic Hepatitis B and Clinical Significance

作　　者：杜希林[1] 刘家秀[2] 刘兴祥[3] 谷茂林 

机构地区：[1]江苏省淮安市淮阴医院,214400 [2]江苏省淮阴卫生学校生化教研组 [3]江苏省淮安市第四人民医院传染科

出　　处：《医学理论与实践》2006年第10期1133-1134,共2页The Journal of Medical Theory and Practice

摘　　要：目的:检测慢性乙型肝炎(CHB)患者血清可溶性细胞间粘附分子-1(sICAM-1)、白细胞介素-18(IL-18)水平,探讨sICAM-1I、L-18变化规律及临床意义。方法:采用ELISA法对慢性乙型肝炎患者血清sICAM-1、IL-18水平进行测定。结果:慢性乙型肝炎患者血清sICAM-1(698.64±270.14)I、L-18(45.94±4.33)水平均明显高于健康对照组sICAM-1(214.62±72.31)(P<0.01)I、L-18(5.13±3.24)(P<0.01);且二者呈正相关(r=0.4464,P<0.01)。结论:sICAM-1I、L-18可能参与慢性肝炎的损伤过程。Objective： To investigate the changes and clinical significance of serum slCAM-1 and IL-18 levels in the patients with chronic hepatitis t3. Methods： The sICAM-1 and IL-18 levels in serum of the patients with chronic hepatitis B were detected by ELISA. Results： The sICAM-1 （698. 64 ±270.14） and IL-18 （45. 94 ± 4. 33） levels were significantly higher than those in healthy groups [sICAM-1（214.62±72. 31） （P〈0. 01）, IL-18（5. 13±3. 24） （P〈0. 01）]; Moreover, there was a close positive correlations between sICAM-1 and IL-18 （r=0. 4464, P〈0. 01）. Conclusion： The sICAM-1 and IL-18 maybe participate in liver inflammatory injury process.

关 键 词：慢性乙型肝炎 细胞粘附分子-1 白细胞介素-18 

分 类 号：R446.2[医药卫生—诊断学] R512.62[医药卫生—临床医学]