非发酵革兰阴性杆菌对头孢哌酮—舒巴坦的敏感性分析  

THE ANALYSIS OF SENSITIVITY OF NON-FERMENTATIVE GRAM-NEGATIVE BACILLI TO CEFOPERAZONE-SULBACTAM

作　　者：徐持华[1] 杨增茹[1] 范泽旭[2] 

机构地区：[1]南阳医学高等专科学校,南阳473058 [2]南阳市中心医院检验科

出　　处：《现代预防医学》2006年第10期1962-1963,共2页Modern Preventive Medicine

摘　　要：目的：通过256株非发酵革兰阴性杆菌对15种β内酰胺类抗生素的敏感性比较，评价头孢哌酮-舒巴坦对非发酵革兰阴性杆菌的抗菌活性，为临床选择抗菌药物提供依据。方法：用VITEK32型全自动细菌分析系统对我院2003年7月至2005年6月临床分离的256株非发酵革兰阴性杆菌进行鉴定药敏试验采用K—B纸片扩散法，判断标准按NC—CLS2002年版进行。结果：非发酵革兰阴性杆菌中分离率占前三位的为铜绿假单胞菌、鲍曼不动杆菌和嗜麦芽窄食单胞菌，分别占非发酵革兰阴性杆菌的40．2％、34．0％和16．0％。非发酵革兰阴性杆菌对头孢呱酮-舒巴坦的敏感度为84．5％～91．8％，明显高于其他β内酰胺类抗生素。结论：临床分离中非发酵革兰阴性杆菌日益增多，头孢呱酮-舒巴坦与其他β内酰胺类抗生素相比，对非发酵革兰阴性杆菌具有良好的抗菌作用，可做为非发酵菌感染的首选药物。Objective： To compare the sensitivity of 256 strains non - fermentative gram - negative bacilli to 15 kinds of β - Lactam antibiotics, evaluate the antibiosis activity of cefoperazone Sulbactam to non - fermentative gram - negative bacilli, aimed at choosing antibitics for clinics. Methods： 256 strains of non- fermentative gram - ndgative bacilli seperated in clinics were analyzed by 32 type VITEK in our hospitals from July 2003 to June 2005, drug paper diffusion method （K - B） was used in susceptibility testing, decision criteria according to NCCLS in 2002. Results： The bacilli with top three separation rate are Pseudomonas aeruginosa, Acimetobacter and baumani stenotropho - monas maltophilia in nonfermentative gram - negative bacilli, accounted for 40.2%, 34.0%and 16.0%. Sensitivity rate of Non fermentative gram- negative bacilli to Cefoperazone- Sulbactam is 84.5% - 91.8%, higher than other β- lactam antibiotice. Conelsions： Cefoperazone - Sulbactam could be the first anti - infection drug to non - fermentative gram - nigative bacilli because it has better antibacterial function than β - lactam antibiotics.

关 键 词：非发酵革兰阴性杆菌 头孢哌酮-舒巴坦 药敏试验 

分 类 号：R519[医药卫生—内科学]