肾衰合剂联合虫草菌粉对慢性肾功能衰竭肾小管损害保护作用的研究  

Research on protecting damage of renal tubules in cases with chronic renal failure by compound preparation for renal failure(肾衰合剂) and cordycepin powder(虫草菌粉)

作　　者：曹阳[1] 张燕敏[1] 杨兴顺[1] 谢小行[1] 

机构地区：[1]武汉市中西医结合医院肾内科,湖北武汉430022

出　　处：《中国中西医结合急救杂志》2006年第5期294-296,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

摘　　要：目的:寻找提高治疗慢性肾功能衰竭(肾衰)肾小管损害临床疗效的最佳中西医结合治疗方法,并探讨其作用机制。方法:61例慢性肾衰患者按随机原则分为两组。治疗组32例,在低蛋白饮食、纠正水和电解质及酸碱平衡失调、控制高血压及抗感染等一般治疗基础上,加用中药肾衰合剂(由黄芪、白术、茯苓、当归、丹参、红花、太子参、木香、厚朴、生地、大黄、牛膝等组成)及虫草菌粉治疗;对照组29例,加服爱西特。两组均治疗2个月。观察治疗前后尿N乙酰βD氨基葡萄糖苷酶(NAG)、2β微球蛋白(2βM G)、溶菌酶(LY S)、24 h尿蛋白定量(24 h U TP)、血肌酐(SC r)、尿素氮(BUN)变化。结果:与治疗前比较,对照组治疗后除BUN差异有显著性外(P<0.05),NAG、2βM G、LY S、24 h U TP和SC r差异均无显著性;治疗组治疗后NAG、2βM G、LY S、24 h U TP、SC r、BUN均显著降低,差异有显著性(P<0.05或P<0.01);与对照组治疗后比较,治疗组除24 h U TP外,余指标差异均有显著性(P<0.05或P<0.01)。治疗组有3例患者出现腹泻,经减少用药量后症状缓解。结论:肾衰合剂联合虫草菌粉对慢性肾衰肾小管损害具有明显的保护作用。Objective： To look for the best method of integrated traditional Chinese and western medicine to treat the damage of renal tubules in cases with chronic renal failure （CRF） and aproach to its therapeutic mechanism. Methods： Sixty-one patients with CRF were randomly divided into two groups, the treatment group （n = 32） and the control group （n = 29）. Those patients in the treatment group received therapy of compound preparation for renal failure [肾衰合剂,including astragalus membranaceus （黄芪）, rhizoma atractylodis macrocephalae （ 白术）, poria （茯苓）, radix angelicae sinensis （ 当归）, radix salviae miltiorrhizae （丹参）, flos carthami （红花）, radix pseudostellariae （太子参）, radix aucklandiae（木香）, cortex magnoliae officinalis （厚朴）, radix rehmanniae glutinosae （生地）, radix et rhizoma rhei （大黄 ） and achyranthes bidentata （牛膝）,etc. ] and cordycepin powder （虫草菌粉） on the basis of general treatment, while the 29 patients in the control group took medicinal charoal orally. The therapy continued for 2 months in both groups. And then, changes of N -acetyl -β- D glucosaminidase （NAG）, β2 -microglobulin （β2 -MG）, lysosome （LYS）, 24 hours urine quantity （24 h U -TP）, serum creatinine （SCr）, and blood urea nitrogen （BUN） et al indexes were investigated and compared before and after the therapy. Results： In the comparison of the indexes after the treatment with those before the therapy in the control group, there were no significant changes in NAG,β2- MG, LYS, 24 h U - TP and SCr （all P〉0.05） with the exception of an obvious decrease in BUN （P〈0. 05）. While in the treatment group the amounts of NAG, β2 -MG, LYS, 24 h U -TP, SCr and BUN in urine were obviously decreased （P〈0. 05 or P〈0. 01）. Compared with the control group, the indexes except for 24 h U - TP in the treatment group were significantly different （P〈20.05 or P〈0. 01）. But there were 3 patients s

关 键 词：中草药 肾小管 肾功能衰竭 慢性 

分 类 号：R277.51[医药卫生—中医学]