四川省获得性耐药结核病患者社会行为危险因素的研究  

Study on socio- behavioral risk factors of acquired drug resistance of tuberculosis in Sichuan province

作　　者：陈建[1] 李宁秀[1] 万康林[2] 杨光京[3] 

机构地区：[1]四川大学公共卫生学院,成都610041 [2]中国疾病预防控制中心传染病预防控制所 [3]四川省结核病防治所

出　　处：《中华流行病学杂志》2006年第10期861-864,共4页Chinese Journal of Epidemiology

摘　　要：目的了解获得性耐药结核病(ADR-TB)患者产生的主要社会行为危险因素。方法选取2002年6月至2005年6月在四川省结核病防治所就诊的949例ADR-TB患者,采用随机系统抽样的方法获得316例作为病例组,按年龄和性别1:1配对同期治疗后仍然对抗结核药敏感患者作为对照。采用问卷调查患者可能导致获得性耐药的社会行为危险因素,并对其危险因素进行条件logistic回归分析,用比值比和可信区间评价它们之间的联系。结果四川省ADR-TB产生的主要社会行为危险因素为经济状况差,DOTS不彻底,患者在治疗中依从性差和治疗过程有中断,其调整的OR值及可信区间分别为5．623(3．462-9．386),8．875(6．136-15．442),6．467(3．942-10．622)和4．906(2．477-10．654)。结论加强对ADR-TB的社会行为危险因素的发现,并有针对性地采取有效的措施,对降低ADR-TB的产生具有重要意义。Objective To explore the socio-behavioral risk factors on acquired drug resistance of tuberculosis （ADR-TB）. Methods Using pair matched case control study,316 ADR-TB samples from 949 cases and 316 controls （pair matched for age and sex） were selected by systematical sampling method and studied through questionnaires. All the study subjects were selected from outpatients of the institute of TB control and prevention ,between June 2002 and June 2005 in Sichuan province. Socio-behavioral risk factors were analyzed with conditional logistic regression and estimated with adjusted odds ratios （OR） and confidence interval（CI）. Results Data showed that the major socio-behavioral risk factors were associated with low economic status, incomplete DOTS, poor compliance and interruption during treatment with adjusted OR and CI as 5. 623（3.462-9.386）,8.875（6. 136-15.442）,6.467（3.942-10.622） and 4. 906 （2.477-10.654） respectively. Conclusion ADR-TB could be controlled by taking effective measures against the socio-behavior risk factors.

关 键 词：结核 获得性耐药 社会行为因素 LOGISTIC回归分析 

分 类 号：R52[医药卫生—内科学]