丹参酮ⅡA在碳糊电极上的伏安行为及其测定  

Voltammetric Behavior and Determination of Tanshinone ⅡA at Carbon Paste Electrode

作　　者：田新娟[1] 宋俊峰[1] 

机构地区：[1]西北大学分析科学研究所,西安710069

出　　处：《分析化学》2006年第9期1283-1286,共4页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金资助项目(No.20475043)

摘　　要：研究了丹参酮ⅡA（TS）在碳糊电极（CPE）上的伏安行为，结果表明：在0．2mol／LBR（pH2．4）的乙醇／水（40：60，V／V）中，TS的羰基发生单电子、单质子的氧化还原反应，该反应是一个有吸附特征的可逆过程；还原产物半醌自由基能稳定存在，这可能是由于CPE中疏水有机相阻止了该自由基的岐化反应。还原峰和氧化峰的峰电位分别为-0．31和-0．24V（vs，SCE），二阶导数氧化峰峰电流与TS浓度在1．2×10^-8—8．2×10^-7mol／L范围内呈线性关系；检出限为4．1×10^-9mol／L。本方法可用于复方丹参片中丹参酮总含量的测定。The vohammetric behavior of tanshinone ⅡA （TS） on carbon paste electrode （CPE） was studied. In 0.2 mol/L BR buffer （pH 2.4）-ethanol/water （40： 60, V/V） medium, the earbonyl group of TS under went a one-electron and one-proton redox reaction at CPE, which was a reversible process with adsorption character. The semiquinone radical of TS as reduction product existed stably on CPE, which might be that hydrophobie organic phase inhibited the disproportionation reaction of the radical of TS. The peak potentials of the reduction and oxidation were -0.31 V and -0.24 V （vs. SCE）, respectively. The second-order derivative oxidation peak current showed a linear relationship with the Concentration of TS in the range of 1.2 × 10^-8 8.2 × 10^-7 mol/L, and the detection＇limit was 4.1 × 10^-9 mol/L. The vohammetrie method proposed can be used to determine the total tanshinone in compound Danshen tablet.

关 键 词：丹参酮ⅡA 半醌自由基 碳糊电极 

分 类 号：O657.1[理学—分析化学]