慢性阻塞性肺病患者并发革兰阴性杆菌肺炎的研究  

Chronic Obstructive Pulmonary Disease Patients with Gram-negative Bacteria Nosocomial Pneumonia

作　　者：周乐翔[1] 杨燕[1] 

机构地区：[1]华中科技大学同济医学院附属襄樊医院,湖北襄樊441021

出　　处：《中华医院感染学杂志》2006年第10期1117-1118,共2页Chinese Journal of Nosocomiology

摘　　要：目的探讨慢性阻塞性肺病(COPD)并发革兰阴性杆菌肺炎的细菌分布及耐药特性,为临床提供诊疗依据。方法用美国Microscan WalkAway-40细菌鉴定仪鉴定细菌,用纸片扩散法进行药敏监测。结果COPD合并肺炎的病原菌以肺炎克雷伯菌和铜绿假单胞菌分离率最高,分别为26.8%和26.2%;病原菌多为耐药菌,仅对亚胺培南、阿米卡星和头孢他啶敏感性较高,对其他常用抗菌药物均呈现较高的耐药性。结论临床对COPD合并肺炎应采取早期预防,及时诊断、合理使用抗菌药物进行治疗的综合性治理措施。OBJECTIVE To study the organism and drug resistance in chronic obstructive pulmonary disease （COPD） patients with Gram-negative bacteria （GNB） nosocomial pneumonia, in order to provide the index to clinician. METHODS The bacteria were tested by Micro WalkAway-40 which made in the USA, the susceptibility test was carried by disk diffusion test. RESULTS The rates of Klebsiella pneumoniae and Pseudornonas aeruginosa among all bacteria were higher, which were 26.8% and 26.2%, respectively; the organisms were almost drug resistant, which were more sensitive to imipenem, amikacin and ceftazidime, and more resistant to other drugs. CONCLUSIONS The hospital should make precautions, diagnose in time, and use antibiotic reasonably.

关 键 词：慢性阻塞性肺病 革兰阴性杆菌 肺炎 耐药性 

分 类 号：R565.1[医药卫生—呼吸系统]