凝固酶阴性葡萄球菌所致婴幼儿败血症  

Infantile Septicemia Induced by Coagulase Negative Staphylococcus

作　　者：武素梅[1] 孟晋华[1] 郑延玲[1] 

机构地区：[1]山西省儿童医院,山西太原030013

出　　处：《中华医院感染学杂志》2006年第10期1167-1168,共2页Chinese Journal of Nosocomiology

摘　　要：目的了解和探讨婴幼儿败血症的主要病原菌及耐药性现状,为临床诊断与治疗提供实验室依据。方法抽取败血症患儿的静脉血于增菌液培养瓶中生长后移种血平板,用法国生物梅里埃公司API系统鉴定328株分离菌。结果凝固酶阴性葡萄球菌(CNS)203株,占分离菌的61.9%,其中表皮葡萄球菌115株(56.6%);溶血葡萄球菌45株(22.1%);里昂葡萄球菌43株(21.1%),耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)分离率为35.5%,MRCNS药敏结果显示多重耐药。结论凝固酶阴性葡萄球菌已成为新生儿血液感染的主要病原菌,MRCNS检出率高且呈多重耐药,糖肽类抗菌药物是治疗MRCNS感染的首选药。OBJECTIVE To investigate the major pathogenic, bacteria and drug resistance in the infantile septicemia and to provide laboratory evidence for clinical diagnosis and treatment. METHODS The venous blood plate was used. RESULTS Totally 328 isolated strains were assayed with French Bio-Merieux API System. Of them, 203 strains of coagulase negative Staphylococcus（CNS）, being 61.9%. 115 strains（56.6%） were S. epidermidis, 45 strains （22. 1%） were S. haemolyticus, and 43 strains（21. 1%） were S. lugdunensis. The isolated rate of meticillin resistant coagulase negative Staphylococcus （MRCNS） was 35.5 %. The drug test for MRCNS showed multiple drug-resistance. CONCLUSIONS MRCNS is the major pathogen in infantile septicemia. The detectable rate of MRCNS is high. Glycopeptide antibiotics are the first-choice drugs for MRCNS infection.

关 键 词：血培养 婴幼儿 凝固酶阴性葡萄球菌 耐药性 

分 类 号：R378.11[医药卫生—病原生物学]