复发性多软骨炎56例临床分析  

Clinical analysis of 56 patients with relapsing polychondritis

作　　者：史旭华[1] 苏金梅[1] 陈志科[1] 张奉春[1] 唐福林[1] 

机构地区：[1]中国医学科学院

出　　处：《中华全科医师杂志》2006年第10期607-609,共3页Chinese Journal of General Practitioners

摘　　要：目的研究复发性多软骨炎的临床特点,提高对本病的认识。方法回顾性分析56例复发性多软骨炎患者的临床及辅助检查资料。结果男女比例1.2:1,发病年龄(46±11)岁。确诊时间(21±35)个月,以耳软骨起病者(8±6)个月,呼吸道起病者(16±31)个月,关节起病者(29±37)个月。受累部位依次为呼吸道40例(71.4%)、耳软骨32例(57.1%)、关节软骨32例(57.1%)、眼部27例(48.2%)、鼻软骨25例(44.6%)、内耳13例(23.2%)。病程初期被误诊为呼吸道感染17例(30.4%)、软骨膜炎9例(16.1%)、肺结核感染6例(10.7%)、类风湿关节炎5例(8.9%)。呼吸道受累的患者中7例接受气管内支架治疗。4例从治疗开始症状一直未缓解者均为呼吸道受累者。结论非耳、鼻部位起病的复发性多软骨炎易被误诊,呼吸道受累比例高且预后差。Objective To investigate clinical characteristics of relapsing polychondritis （RP） and to improve early recognition for it. Methods Clinical and laboratory data of 56 patients with RP were analyzed retrospectively. Results Ratio of number of male patients to female ones was 1.2. Age at onset was （46±11） years （ranging from 27 to 71） and average interval between onset and diagnosis was （21±35） months, （8±6）, （16±31） and （29±37） months for patients initial onset with auricle, respiratory tract and joints involved, respectively. Site involved included airway in 40 patients （71.4%）, auricle in 32 （57.1%）, joints in 32 （57.1%）, eyes in 27 （48.2%）, nasal chondritis in 25 （44.6%） and inner ear in 13 （23.2%）. At initial stage of the course, 17 patients were misdiagnosed as respiratory infection （30.4%）, nine as perichondritis （16.1%）, six as pulmonary tuberculosis （10.7%）, five as rheumatoid arthritis （8.9%）. Seven of 40 patients with airway involvement received metallic stents for their tracheobronchial stenosis. Four patients whose condition never improved after regular therapy all had respiratory involvement. Conclusions Patients of RP with initial onset at non-auricle, non-nasal sites tended to be misdiagnosed. Prevalence of airway involvement was not so low with a poor prognosis in patients of RP.

关 键 词：多发性软骨炎 复发性 回顾性研究 诊断 

分 类 号：R681.3[医药卫生—骨科学]